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This review highlights recent developments in the study of the properties and applications of lactic acid bacteria (LAB). The involvement of LAB in human life has a long history, especially in food production, where their ability to lactic acid fermentation has been crucial in extending the shelf life of perishable raw materials. However, in recent decades, the role of lactic acid bacteria has steadily expanded covering new areas of biotechnology, particularly, in the development of biosynthetic products that find application in a wide range of areas. Certain strains of lactic acid bacteria are recognized as probiotics, and their incorporation into food products promotes the development of functional foods that offer enhanced health benefits to consumers. Traditionally, LAB have been used in food preservation. Beyond their technological functions, they contribute to extending the shelf life of fermented products by inhibiting spoilage and pathogenic microorganisms through the production of antimicrobial compounds like bacteriocins and reuterin. Additionally, LAB are recognized as producers of valuable secondary metabolites, such as exopolysaccharides and polyhydroxyalkanoates, as well as primary metabolites, including enzymes and gamma-aminobutyric acid. They also show potential in the biosynthesis of metal nanoparticles and the development of innovative packaging materials. This review aimed to highlight the wide range of potential applications for lactic acid bacteria, with a focus on novel and emerging trends in their biotechnological utilization.
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http://dx.doi.org/10.1007/s11274-025-04499-0 | DOI Listing |
Lung
September 2025
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Introduction: Lactate has emerged as a multifunctional signaling molecule regulating various physiological and pathological processes. Furthermore, lactylation, a newly identified posttranslational modification triggered by lactate accumulation, plays significant roles in human health and diseases. This study aims to investigate the roles of lactate/lactylation in respiratory diseases.
View Article and Find Full Text PDFAnal Chem
September 2025
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, P. R. China.
Electroactive bacteria (EAB) hold great promise for the development of electrochemical biosensors given their unique ability to transfer electrons extracellularly via specialized pathways, a process termed extracellular electron transfer (EET). Ongoing research aims to overcome current limitations and fully harness the potential of EABs for high-performance biosensing applications. Herein, we report the fabrication of an electrochemical microsensor based on biomineralized electroactive bacteria, specifically MR-1.
View Article and Find Full Text PDFMater Today Bio
October 2025
Department of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China.
Atherosclerosis (AS) is a chronic inflammatory disease driven by endothelial dysfunction, vascular smooth muscle cell proliferation, and insufficient resolution of inflammation. Nitric oxide (NO) plays a crucial role in vascular homeostasis by promoting endothelial cell proliferation, maintaining endothelial integrity, suppressing smooth muscle cell hyperplasia, and exerting potent anti-inflammatory effects. However, clinical application of NO is hindered by its short half-life, lack of targeting, and uncontrolled release.
View Article and Find Full Text PDFFront Nutr
August 2025
College of Food Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.
Introduction: Fermented buffalo milk products from South Asia remain an underexplored source of microbial diversity with potential health-promoting benefits. This study investigates the probiotic and industrial suitability of lactic acid bacteria (LAB) and non-LAB isolates from traditional Pakistani dairy, addressing gaps in region-specific probiotic discovery.
Methods: Forty-seven bacterial isolates were obtained from fermented buffalo milk products (yogurt and cheese).
Biochem Biophys Rep
June 2025
The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, China.
Background: SLC16A3, a highly expressed H + -coupled symporter, facilitates lactate transport via monocarboxylate transporters (MCTs), contributing to acidosis. Although SLC16A3 has been implicated in tumor development, its role in tumor immunity remains unclear.
Methods: A pan-cancer analysis was conducted using datasets from The Cancer Genome Atlas, Cancer Cell Line Encyclopedia, and Genotype-Tissue Expression projects.