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We present the case of a 63-year-old male patient with a history of chronic obstructive pulmonary disease (COPD), heavy smoking, and poor dental hygiene, who presented with progressive dyspnea, fever, and a productive cough. The patient was initially evaluated for pneumonia, but a chest radiograph revealed a right-sided pleural effusion. Further analysis of the pleural fluid showed an exudative effusion. Histopathological examination of a pleural biopsy sample identified gram-positive branching filamentous rods with yellow sulfur granules, consistent with a diagnosis of pulmonary actinomycosis. The patient was initially treated with intravenous amoxicillin/sulbactam, later switched to oral amoxicillin. This case highlights a rare clinical presentation of pleural effusion in a patient with pulmonary actinomycosis.
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http://dx.doi.org/10.4314/ejhs.v35i3.10 | DOI Listing |
Background: Actinomyces graevenitzii is a relatively uncommon Actinomyces species, which is an oral species and predominantly recovered from respiratory locations [1,2]. It is a gram-positive anaerobic bacteria or microaerobic filamentation bacteria, which can induce pyogenic and granulomatous inflammation characterized by swelling and concomitant pus, sinus formation, and the formation of yellow sulfur granules. All tissues and organs can be infected; the most common type involves the neck and face (55%), followed by the abdominal and pelvic cavities (20%).
View Article and Find Full Text PDFEthiop J Health Sci
May 2025
Sudan University of Science and Technology, Faculty of medicine Khartoum, Khartoum, SD.
We present the case of a 63-year-old male patient with a history of chronic obstructive pulmonary disease (COPD), heavy smoking, and poor dental hygiene, who presented with progressive dyspnea, fever, and a productive cough. The patient was initially evaluated for pneumonia, but a chest radiograph revealed a right-sided pleural effusion. Further analysis of the pleural fluid showed an exudative effusion.
View Article and Find Full Text PDFFront Med (Lausanne)
July 2025
Department of Respiratory and Critical Care Medicine, Fuyang Infectious Disease Clinical College of Anhui Medical University, Fuyang, Anhui, China.
The emergence of next-generation sequencing (NGS) has significantly improved the detection rate of Actinomyces species in pulmonary actinomycosis (PA), a rare and diagnostically challenging infectious disease. Here, we report a case of an elderly patient with a history of pyoderma gangrenosum who presented with pulmonary infiltrates and was subsequently hospitalized. Both histopathological examination of tracheoscopic biopsy specimens and NGS analysis of bronchoalveolar lavage fluid (BALF) confirmed infection with ().
View Article and Find Full Text PDFMedicine (Baltimore)
July 2025
Department of Pulmonology, Chengdu Sixth People's Hospital, Chengdu, China.
Rationale: Legionella pneumophila (LP) and Tropheryma whipplei (TW) have been identified as pathogens that can coexist in sewage environments, which can both cause pneumophila and can impact various organs, leading to extrapulmonary manifestations. It is rare to find literature on pneumonia caused by atypical pathogens, such as the combination of LP and TW. There are no reports on specific drug treatments for such combined infections.
View Article and Find Full Text PDFJ Neurosurg Case Lessons
June 2025
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Background: Actinomycosis is a rare, globally distributed disease with an annual incidence of 1 case per 300,000 persons. It classically manifests as a cervicofacial disease with sinus tract formation and purulent discharge with or without sulfur granules. Spinal compromise occurs in less than 5% of cases; however, it causes significant morbidity associated with neurological impairment.
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