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Undifferentiated Small Round Cell Sarcomas of Bone. | LitMetric

Undifferentiated Small Round Cell Sarcomas of Bone.

Surg Pathol Clin

Department of Diagnostic Pathology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan; Rare Cancer Center, National Cancer Center Hospital, Tokyo, Japan. Electronic address:

Published: September 2025


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Article Abstract

Undifferentiated small round cell sarcomas are a heterogeneous group of high-grade sarcomas of uncertain histogenesis. In this review, the key clinicopathological, immunohistochemical, and molecular characteristics of select entities that commonly originate from bones (ie, Ewing sarcoma, BCOR::CCNB3 sarcoma, and EWSR1::NFATC2 sarcomas) are summarized. CIC-rearranged sarcomas are briefly discussed because they rarely arise from bone. Relevant immunohistochemical markers, differential diagnoses, and practical pitfalls are also reviewed.

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http://dx.doi.org/10.1016/j.path.2025.01.001DOI Listing

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