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ECG is an essential diagnostic tool that offers important insight into a person's cardiac and general health. The rise of intelligent wearable devices has opened a new avenue for clinicians and individuals to capture long term ECG data-albeit with fewer leads than the 12 leads that are typically used clinically, which can be vital for identifying and addressing health concerns. In this work, a multi-task convolutional neural network (CNN) classifier was used to study the influence of various combinations of ECG leads in interpretation of 71 cardiac statements spanning cardiac diagnostics, form, and rhythm. Results of this analysis suggest that the subset of limb leads I and II and chest leads V1, V3, and V6 can be used to identify several cardiac statements without loss of performance (average macro AUC of 0.903) when compared to a model trained using all 12- leads (average macro AUC of 0.905; p = 1). A hybrid CNNLSTM (long short-term memory) model was developed to reconstruct the missing chest leads. The highest performing lead reconstructor achieved an average R2 score of 0.835 when reconstructing three chest leads. This architecture was proposed as the foundation for a wearable system that could record a limited number of ECG leads while also providing a 12-lead ECG for clinical applications.
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http://dx.doi.org/10.1109/JBHI.2025.3592852 | DOI Listing |
EMBO Mol Med
September 2025
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, 100071, Beijing, China.
Traditional live attenuated vaccines (LAVs) are typically developed through serial passaging or genetic engineering to introduce specific mutations or deletions. While viral RNA secondary or tertiary structures have been well-documented for their multiple functions, including binding with specific host proteins, their potential for LAV design remains largely unexplored. Herein, using Zika virus (ZIKV) as a model, we demonstrate that targeted disruption of the primary sequence or tertiary structure of a specific viral RNA element responsible for Musashi-1 (MSI1) binding leads to a tissue-specific attenuation phenotype in multiple animal models.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Health Services Research, and CAPHRI School for Public Health and Primary Care, Aging and Long Term Care Maastricht, Maastricht, the Netherlands.
Background: Older patients presenting with nonspecific complaints (NSC) in the Emergency Department (ED) pose diagnostic challenges. The lack of clear symptoms leads to high misdiagnosis rates, extended hospital stays, and functional impairment. However, limited research exists on diagnostic test utilization for this population.
View Article and Find Full Text PDFCureus
August 2025
Respiratory Medicine, Dartford and Gravesham NHS Trust, Dartford, GBR.
Pressure-dependent pneumothorax is an under-recognized but clinically significant phenomenon that complicates pleural fluid drainage, particularly in patients with non-expandable lungs due to malignancy or chronic pleural fibrosis. Unlike pressure-independent pneumothorax, this condition arises from the pronounced transpleural pressure gradient generated during therapeutic thoracentesis or chest drainage. This negative pressure transiently distorts the visceral pleura, allowing air to enter the pleural space until an equilibrium is reached.
View Article and Find Full Text PDFCureus
August 2025
Emergency Medicine, NMC Royal Hospital, Khalifa City, ARE.
In adults having chest pain, ST-segment elevation, both benign and pathologic, is a common finding seen on electrocardiograms (ECGs). Some degree of ST-segment elevation is common, especially in young men. Commonly referred to as benign early repolarization (BER), this elevation is seen in the precordial leads.
View Article and Find Full Text PDFMultimed Man Cardiothorac Surg
September 2025
Institute of Chest Surgery, Medanta, Gurugram, India
Birt-Hogg-Dubé syndrome (BHDS) is an autosomal dominant inherited disorder caused by mutation in a tumour suppressor gene, FLCN, leading to skin tumours (fibrofolliculomas), renal tumours and pulmonary cysts. Lung involvement is predominantly observed in 70% of the cases of BHDS, manifesting in the form of recurrent primary spontaneous pneumothorax. This video tutorial showcases the surgical management of recurrent right primary spontaneous pneumothorax in a young adult with a history of multiple episodes of bilateral pneumothorax managed by surgical intervention previously.
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