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http://dx.doi.org/10.1007/s10620-025-09233-2 | DOI Listing |
JACC Case Rep
September 2025
Cardiology Department, CHU Clermont-Ferrand, Clermont-Ferrand, France; Université Clermont Auvergne, CHU Clermont-Ferrand, CNRS, SIGMA Clermont, Institut Pascal, Clermont-Ferrand, France.
Background: Cardiac syncope due to sinus arrest may result from either a vasovagal cardioinhibitory mechanism or an intrinsic sinus node dysfunction.
Case Summary: A 67-year-old woman with a recently diagnosed right hilar mass presented with new-onset episodes of syncope associated with sinus arrest. Resting electrocardiogram was normal, and no electrolyte abnormalities were identified.
Front Oncol
August 2025
Division of Hematology, Department of Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Extramedullary relapse of acute lymphoblastic leukemia (ALL) is usually associated with poor prognosis. Chimeric antigen receptor T cell (CAR-T cell) therapy followed by allogeneic hematopoietic stem cell transplantation is beneficial for relapsed/refractory (r/r) B cell acute lymphoblastic leukemia (B-ALL). Here, we report a B-ALL patient with extramedullary relapse involving several organs, including multiple lymph nodes and the breast, kidney, uterus and pancreas.
View Article and Find Full Text PDFClin J Gastroenterol
August 2025
Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Eosinophilic infiltration of the esophageal muscular layer, known as eosinophilic esophageal myositis (EoEM), is an exceptionally rare condition that can mimic primary motility disorders such as achalasia. We present the case of a 72-year-old male with progressive dysphagia and significant weight loss, whose high-resolution manometry revealed findings consistent with achalasia, but with unusually elevated lower esophageal sphincter pressures. Surgical myotomy was performed and histopathological analysis unexpectedly revealed intense eosinophilic infiltration of the muscularis propria.
View Article and Find Full Text PDFWe describe a rare case of a 64-year-old male who developed life-threatening thrombocytopenia two weeks after undergoing endovascular aneurysm repair (EVAR) for an abdominal aortic aneurysm. He presented with mucocutaneous bleeding manifestations, and laboratory findings revealed a critically low platelet count (<2 × 10/L). An extensive workup identified a positive stool antigen test and autoimmune markers, including antinuclear antibody (ANA) and anti-double-stranded DNA (anti-dsDNA) antibodies.
View Article and Find Full Text PDFNat Commun
August 2025
Dept of Earth Sciences, University of Cambridge, Cambridge, UK.
The cratonic 'roots' of Earth's major continents extend to depths of over 160 km and have remained stable for more than 2.5 billion years due to buoyant, refractory harzburgites formed by Archean mantle melting. However, mantle harzburgites from some global cratons (e.
View Article and Find Full Text PDF