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Background: Breast cancer care has become increasingly complex, lending itself to fellowship-based specialization. However, breast surgery expertise remains central to general surgery training. We hypothesized that residents entering breast surgical oncology (BSO) fellowship have more exposure to breast surgery and log a higher number of breast cases compared with all other graduating residents.
Materials And Methods: Demographics, program characteristics, and Accreditation Council for Graduate Medical Education (ACGME) case logs were collected for graduates from 20 general surgery residency programs in the US Resident OPerative Experience (ROPE) Consortium from 2010 to 2020. BSO fellowship matriculants (BSO group) were compared to those entering other surgical fellowships or general surgery practice (non-BSO group).
Results: Among 1343 graduates, 45 (3.4%) matriculated into BSO fellowship. BSO matriculants were more often female (89% versus 34%, p < 0.0001). Demographic, program, and institutional variables were otherwise similar (all p > 0.05). The BSO group logged fewer total procedures (median, 976 versus 1039), consistent across Surgeon Junior and Teaching Assistant roles and multiple operative domains, including alimentary tract, pediatric, plastics, thoracic, trauma, and vascular (all p < 0.05). However, BSO group logged more breast cases (74 versus 50, p < 0.0001), despite comparable access to a breast surgery rotation (64% versus 64%) and fellowship-trained faculty (82% versus 84%; both p > 0.05).
Conclusions: Future BSO matriculants performed 50% more breast cases during residency but logged fewer total cases across multiple operative domains. These residents may develop early interest in breast surgery and subsequently tailor their training. Further mixed-methods studies are needed to understand these findings and their implications for trainees pursuing breast surgery.
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http://dx.doi.org/10.1245/s10434-025-17853-1 | DOI Listing |
Genome Biol
September 2025
Center for Genomic Medicine, Cardiovascular Research Center, , Massachusetts General Hospital Simches Research Center, 185 Cambridge Street, CPZN 5.238,, Boston, MA, 02114, USA.
Background: Rare genetic variation provided by whole genome sequence datasets has been relatively less explored for its contributions to human traits. Meta-analysis of sequencing data offers advantages by integrating larger sample sizes from diverse cohorts, thereby increasing the likelihood of discovering novel insights into complex traits. Furthermore, emerging methods in genome-wide rare variant association testing further improve power and interpretability.
View Article and Find Full Text PDFBMC Endocr Disord
September 2025
Internal Medicine Department, Faculty of Medicine, Beni-Suef University, Beni-Suef City, 62514, Egypt.
Background: Thyroid nodules (TNs) are frequent and often benign. Accurately differentiating between benign and malignant nodules is crucial for proper management. This research aims to use ultrasonography to examine TNs and identify possible risk factors in order to improve patient outcomes and diagnostic accuracy.
View Article and Find Full Text PDFJ Robot Surg
September 2025
Department of General Surgery, Giglio Hospital Foundation, Cefalu', Italy.
The adoption of robotic pancreatectomy has grown significantly in recent years, driven by its potential advantages in precision, minimally invasive access, and improved patient recovery. However, mastering these complex procedures requires overcoming a substantial learning curve, and the role of structured mentoring in facilitating this transition remains underexplored. This systematic review and meta-analysis aimed to comprehensively evaluate the number of cases required to achieve surgical proficiency, assess the impact of mentoring on skill acquisition, and analyze how outcomes evolve throughout the learning process.
View Article and Find Full Text PDFNat Aging
September 2025
Aging Biomarker Consortium (ABC), Beijing, China.
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
September 2025
Department of Surgery, Mannheim School of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Purpose: The study aims to compare the treatment recommendations generated by four leading large language models (LLMs) with those from 21 sarcoma centers' multidisciplinary tumor boards (MTBs) of the sarcoma ring trial in managing complex soft tissue sarcoma (STS) cases.
Methods: We simulated STS-MTBs using four LLMs-Llama 3.2-vison: 90b, Claude 3.