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Vertebrates depend on their musculoskeletal system for locomotion, manipulation, interaction with their environment, and more. The robustness and efficiency of animal locomotion are difficult to achieve in robots because their hardware does not replicate the mechanics and performance of animal bodies. Moreover, many state-of-the-art soft actuators are ill-suited as muscles in artificial musculoskeletal systems for deployable, task-capable robots. This study presents an electrically-driven, architected soft actuator that can be assembled into artificial musculoskeletal systems. The fully 3D printed actuators linearly extend and contract through the rotation of an integrated servo motor. They comprise a thermoplastic polyurethane handed shearing auxetic (HSA) and origami bellows structure. Together, these structures transmit torque, stretch, and resist torsional deflection in a manner that produces large linear actuation and force output up to 59 mm (or 30% strain) and 75 N, respectively. It showcases the actuator's performance as artificial muscles in a battery-powered, human-scale leg that can use three muscles to kick a ball. When accounting for the weight of auxiliary hardware, the actuators exhibit power and energy densities that are four orders of magnitude higher than for leading soft artificial muscles. The soft actuators represent a step toward providing robots with bioinspired musculoskeletal systems for animal-like abilities.
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http://dx.doi.org/10.1002/adma.202501290 | DOI Listing |
J Imaging Inform Med
September 2025
Department of Biomedical Engineering, Gachon University, Seongnam-Si 13120, Gyeonggi-Do, Republic of Korea.
To develop and validate a deep-learning-based algorithm for automatic identification of anatomical landmarks and calculating femoral and tibial version angles (FTT angles) on lower-extremity CT scans. In this IRB-approved, retrospective study, lower-extremity CT scans from 270 adult patients (median age, 69 years; female to male ratio, 235:35) were analyzed. CT data were preprocessed using contrast-limited adaptive histogram equalization and RGB superposition to enhance tissue boundary distinction.
View Article and Find Full Text PDFEur J Pediatr
September 2025
Paediatric Pain and Palliative Care Service, Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy.
Purpose: This study aimed to describe the structure, patient characteristics, and preliminary clinical outcomes of a dedicated interdisciplinary outpatient clinic for paediatric chronic and complex pain in Italy, with a focus on the feasibility of implementing a biopsychosocial care model.
Methods: We conducted a retrospective review of all patients referred to the Paediatric Specialised Pain Clinic of the University of Padua between January 2023 and May 2024. Data on demographics, clinical diagnoses, pain characteristics, treatments, and follow-up outcomes were collected.
Physiol Rep
September 2025
Department of Physiology, Nutrition and Biomechanics, Swedish School of Sport and Health Sciences, Stockholm, Sweden.
Human skeletal muscle comprises slow-twitch (type I) and fast-twitch (type II) fibers. Fiber type-specific analyses often require manual isolation of fibers, necessitating effective tissue preservation. While freeze-drying remains the standard, alternative preservation methods such as RNAlater and RNAlater-ICE are increasingly used.
View Article and Find Full Text PDFBMJ Case Rep
September 2025
Radiology, Children's Health Ireland at Temple Street, Dublin, Leinster, Ireland.
Slipped capital femoral epiphysis (SCFE) is a rare occurrence in the paediatric hip. Diagnosis is challenging. It may have an insidious onset.
View Article and Find Full Text PDFMethods Cell Biol
September 2025
Department of Cell Biology and Histology, University of the Basque Country UPV/EHU, Leioa, Spain. Electronic address:
Human Dental Pulp Stem Cells (hDPSCs) represent a remarkable cell source for tissue engineering and regenerative medicine, offering significant potential for use in personalized medicine and autologous therapies. Decellularized extracellular matrix (ECM)-derived biological scaffolds show excellent properties for supporting cell delivery and growth in both in vitro and in vivo applications. These scaffolds provide essential biochemical cues that regulate cellular functions and offer a more accurate representation of the in vivo environment.
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