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http://dx.doi.org/10.1016/j.arbres.2025.06.016 | DOI Listing |
J Med Cases
August 2025
Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL, USA.
Hypereosinophilic syndrome (HES) is a hematologic disorder characterized by an increased absolute eosinophil count (AEC) that can lead to tissue infiltration and damage. Idiopathic HES (iHES) comprises a subset of patients with HES, in which a reactive cause such as infections or an inflammatory process cannot be identified, and clonality is not demonstrable. iHES remains a challenge to treat since there is no specific mutation to target.
View Article and Find Full Text PDFSci Rep
September 2025
Division of Pulmonary, Asthma, Cystic Fibrosis, and Sleep, Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA, 30322, USA.
Alcohol exposure augments the expression and signaling of transforming growth factor-beta (TGFβ), leading to fibroproliferation. We showed that inhibition of TGFβ receptor type 1 (TGFβR1) mitigates the effect of alcohol in the lung. We further demonstrated that alcohol modulates TGFβ signaling, partly through its ability to modify microRNA (miRNA or miR) expressions in the lung.
View Article and Find Full Text PDFJ Inflamm Res
August 2025
Department of Respiratory, The First People's Hospital of Jiande, Hangzhou, Zhejiang, People's Republic of China.
Introduction: Asthma is a chronic inflammatory airway disease. 5-methylcytosine (m5C), an RNA modification, plays an unclear role in asthma pathogenesis. This study aimed to investigate the mechanism of m5C modification in asthma development.
View Article and Find Full Text PDFMethodsX
June 2025
Department of Mathematics, Birla Institute of Technology and Science, Pilani, India.
Air pollution poses a significant challenge to public health and the global environment. The Industrial Revolution, advancing technology and society, led to elevated air pollution levels, contributing to acid rain, smog, ozone depletion, and global warming. Poor air quality increases risks of respiratory inflammation, tuberculosis, asthma, chronic obstructive pulmonary disease (COPD), pneumoconiosis, and lung cancer.
View Article and Find Full Text PDFCurr Allergy Asthma Rep
August 2025
School of Electrical Engineering, Hebei University of Science and Technology, No. 26 Yuxiang Street, Yuhua District, Shijiazhuang, Hebei, China.
Purpose Of Review: This review aims to explore an effective and scalable approach for early asthma detection using cough sounds. The main objective is to evaluate whether a multi-model deep learning fusion framework can improve diagnostic accuracy and generalizability in real-world settings.
Recent Findings: Recent research in respiratory sound analysis has demonstrated the potential of deep learning models in detecting pulmonary diseases.