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5-HT6R-ATR-primary cilia network supports morphine-related memory extinction in the medial prefrontal cortex.
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College of Forensic Medicine, Key Laboratory of National Health Commission for Forensic Medicine, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Drug addiction involves pathological learning and memory with serious personal and societal effects. Primary cilia on the cell surface are crucial for signal transduction. The 5-HT6R, highly localized in primary cilia, is linked to cognitive and emotional disorders, but its role in morphine-related reward memory is unclear.
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Western Australian Herbarium, Biodiversity and Conservation Science, Department of Biodiversity, Conservation and Attractions, Bentley 6983 WA, Australia.
The tribe Lasiopetaleae (Malvaceae subfamily Byttnerioideae) consists of nine genera largely distributed in Australia. Boundaries between genera have historically been contentious, with many species being described in one genus and variously transferred to others. Previous phylogenetic studies using morphology and plastid DNA have mostly resolved relationships within the tribe except for a group of genera allied to Lasiopetalum.
View Article and Find Full Text PDFActivation of CISD2 as a protective strategy against doxorubicin-induced cardiotoxicity.
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Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, 350, Taiwan; Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan; Center for Healthy Longevity and Aging Sciences, National Yang Ming Chia
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When recalling past events, patterns of gaze position and neural activity resemble those observed during the original experience. We hypothesized that these two phenomena, known as gaze reinstatement and neural reactivation, are linked through a common process that underlies the reinstatement of past experiences during memory retrieval. Here, we tested this proposal based on the viewing and recall of a narrative movie, which we assessed through functional magnetic resonance imaging, deep learning-based gaze prediction, and language modeling of spoken recall.
View Article and Find Full Text PDFEffects of cortical thickness, volume, and memory performance on age differences in neural reinstatement of scene information.
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Center for Vital Longevity, University of Texas at Dallas, 1600 Viceroy Dr., Suite 800, Dallas, TX 75235, United States.
The strength of neural reinstatement, a correlate of episodic memory retrieval, reportedly reflects the amount and fidelity of mnemonic content and is weaker in older than younger adults, especially for scene memoranda. Based on evidence that age-related declines in cortical thickness and volume contribute to age-related cognitive decline, we analyzed functional magnetic resonance imaging data acquired from healthy young and older adults to examine relationships between cortical thickness, cortical volume, age, and scene-related reinstatement in 3 cortical regions implicated in scene processing: the parahippocampal place area, medial place area, and occipital place area. A "reinstatement index" was estimated from functional magnetic resonance imaging data collected during tests of source memory for scene images, and multiple regression analyses were employed to examine the effects of the variables of interest on scene reinstatement.
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