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Background: Evaluation of health problems in the Para athlete cohort is well-established. Nonetheless, analyses of the association between mental health and injury, illness or variability of training and competition are spare. Therefore, the purpose of this prospective observational study was to assess this potential relationship in a cohort of Para athletes.
Methods: Continuous health monitoring of German Paralympic athletes using the Oslo Sports Trauma Centre (OSTRC) questionnaire and Patient Health Questionnaire-4 (PHQ-4) on a weekly basis. Additionally, primary sporting activity, training exposure, and subjective training intensity per week were recorded. PHQ-4 scores in relation to substantial health problems were analyzed [mean (M) and 95% confidence interval (95%CI)]. A regression tree analysis was used to analyze the relationship between the independent variables age, sex, impairment type, and sport, as well as the stress level, mood, PHQ-4 sum score, subjective training intensity, training exposure, main weekly activeness, type of health problem, and if it was a substantial health problem, 4 consecutive weeks and dependent variable, the PHQ-4 sum score in the fifth week.
Results: Over an observation period of 124 weeks, 122 Para athletes reported a total of 438 health problems and a mean PHQ-4 score of = 1.3 (95%CI: 1.3-1.4). Highest mean score was observed during illnesses (M = 2.6; 95%CI: 2.2-3). The regression tree identified the leading PHQ-4 score and current mood or stress level as the primary predictors, while all other independent variables did not contribute to the model's prediction.
Conclusion: The findings suggest a potential impact of physical health concerns on mental health, though these, and variations in training or competition were not identified as predictors for the mental health status in a Para athlete cohort. In addition, mean PHQ-4 scores remained below clinical cut-off values, suggesting the need for individualized support to ensure adequate management.
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http://dx.doi.org/10.3389/fpsyg.2025.1628494 | DOI Listing |
Eat Disord
September 2025
Center for Eating and feeding Disorders Research (CEDaR), Psychiatric Center Ballerup, Mental Health Services in the Capital Region of Denmark.
Proc Natl Acad Sci U S A
September 2025
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240.
Major depressive disorder affects millions worldwide, yet current treatments require prolonged administration. In contrast, ketamine produces rapid antidepressant effects by blocking spontaneous N-Methyl-D-Aspartate (NMDA) receptor signaling, which lifts the suppression of protein synthesis and triggers homeostatic synaptic plasticity. Here, we identify a parallel signaling pathway involving metabotropic glutamate receptor 5 (mGluR5) that promotes rapid antidepressant-like effects.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Lübeck, Lübeck, Germany.
Importance: Patients with inflammatory rheumatic diseases (IRDs) frequently experience psychological distress; however, access to psychological support remains limited.
Objective: To investigate the effectiveness of a digital psychological intervention for individuals with IRDs.
Design, Setting, And Participants: Participants aged 18 years or older were recruited across Germany between February 22 and June 4, 2024, if they had been diagnosed with rheumatoid arthritis, psoriatic arthritis, or systemic lupus erythematosus and reported psychological distress and reduced quality of life.
J Gambl Stud
September 2025
Department of Psychology and Azrieli Israel Center for Addiction and Mental Health, The Hebrew University of Jerusalem, Jerusalem, Israel.
Research suggests that Problem Gambling (PG) may result from maladaptive emotional regulation strategies aimed at escaping emotions and stress caused by negative life events and trauma. The current study, aimed to examine the effect of exposure to the mass trauma of October 7, 2023 terror attack and the consequent Swords of Iron war in Israel, and difficulties in emotional regulation on PG. We utilized longitudinal data of self-reports in the Problem Gambling Severity Index collected before the terror attack (April 2022) and during the Swords of Iron war (December 2023, March 2024, June 2024; N = 899) from a large sample of adult Jewish Israelis.
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