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The dysregulation of the autonomic nervous system (ANS) activity notably contributes to the onset and progression of numerous diseases, including lifestyle-related and psychiatric disorders. This necessitates the development of effective nonpharmacological methods for regulating ANS function for therapeutic purposes and disease prevention. This study examined how the presence or absence of the inaudible high-frequency component (HFC) of sounds-which activates deep-brain structures-affects the ANS regulatory function. Under the N-back task condition, which requires concentration, exposure to sounds with HFC resulted in significantly higher sympathetic and parasympathetic nervous activities compared to sounds without HFC. Conversely, under the relaxation condition, the sounds with HFC significantly suppressed sympathetic nervous activity relative to sounds without HFC. Therefore, sounds with HFC may flexibly adjust the sympathetic and parasympathetic nervous activities based on situational demands.
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http://dx.doi.org/10.1038/s41598-025-11190-9 | DOI Listing |
Sci Rep
July 2025
Department of Information Medicine, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan.
The dysregulation of the autonomic nervous system (ANS) activity notably contributes to the onset and progression of numerous diseases, including lifestyle-related and psychiatric disorders. This necessitates the development of effective nonpharmacological methods for regulating ANS function for therapeutic purposes and disease prevention. This study examined how the presence or absence of the inaudible high-frequency component (HFC) of sounds-which activates deep-brain structures-affects the ANS regulatory function.
View Article and Find Full Text PDFSci Rep
November 2022
Department of Research and Development, Foundation for Advancement of International Science, Tsukuba, Japan.
Although stress significantly impacts on various metabolic syndromes, including diabetes mellitus, most stress management techniques are based on psychological and subjective approaches. This study examined how the presence or absence of the inaudible high-frequency component (HFC) of sounds, which activates deep-brain structures, affects glucose tolerance in healthy participants using the oral glucose tolerance test (OGTT). Sounds containing HFC suppressed the increase in glucose levels measured by incremental area under the curve in the OGTT compared with the otherwise same sounds without HFC.
View Article and Find Full Text PDFJ Chem Eng Data
January 2022
Applied Chemicals and Materials Division, National Institute of Standards and Technology, Boulder, Colorado 80305, United States.
Difluoromethane (HFC-32, DFM), with a global warming potential (GWP) of 677, is of interest as a pure refrigerant and as a component in low-GWP refrigerant mixtures. Additionally, difluoromethane has recently been identified as a safe, liquefied-gas electrolyte material in batteries. Using state-of-the-art instruments for measurements, this paper presents new liquid-phase speed of sound and vapor-phase density data for difluoromethane.
View Article and Find Full Text PDFLancet Infect Dis
March 2022
Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA. Electronic address:
PLoS One
January 2015
Department of Research and Development, Foundation for Advancement of International Science, Tsukuba, Japan.
The hypersonic effect is a phenomenon in which sounds containing significant quantities of non-stationary high-frequency components (HFCs) above the human audible range (max. 20 kHz) activate the midbrain and diencephalon and evoke various physiological, psychological and behavioral responses. Yet important issues remain unverified, especially the relationship existing between the frequency of HFCs and the emergence of the hypersonic effect.
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