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Article Abstract
This case-control study investigated the association between herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and the risk of head and neck cancer (HNC), considering established risk factors such as tobacco, alcohol, and HPV-16 infection. Analysis of 164 HNC cases and 295 controls using serological and ELISA assays revealed no independent association between HSV seropositivity and overall HNC risk. However, an inverse relationship was observed among individuals co-exposed to HSV and known carcinogens, suggesting a potential modulatory role of HSV in HNC development. Notably, co-infection with HSV and HPV-16 E6/E7 was linked to lower cancer risk than HPV-16 infection alone. These findings warrant further mechanistic and longitudinal studies to clarify the immunovirological interactions and their implications for cancer prevention.
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| http://dx.doi.org/10.1016/j.oraloncology.2025.107516 | DOI Listing |
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