Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
One of the most common clinical manifestations of inherited platelet hyperaggregability also known as sticky platelet syndrome (SPS) is migraine. The aim of this study was to assess the role of single nucleotide polymorphisms (SNPs) of platelet endothelial aggregation receptor 1 () and murine retrovirus integration site 1 () genes in pathogenesis of SPS associated with migraine. Hundred patients with SPS and migraine as well as two hundred and seven patients with SPS and without migraine as a control group were enrolled. SPS was diagnosed by light transmission aggregometry (LTA) according to the method and criteria described by Mammen and Bick. Two SNPs within gene (rs12041331 and rs12566888) and two SNPs within gene (rs7940646 and rs1874445) were assessed using High resolution melting (HRM) analysis. Minor allele frequencies for both SNPs within and in patients with SPS and history of migraine as well as haplotypes did not significantly differ compared to the SPS control group. The study also suggests SPS as a complex interaction of several genes resulting in possible polygenic phenotype of migraine in SPS patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290346 | PMC |
| http://dx.doi.org/10.1177/10760296251362723 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Selected and Gene Polymorphisms in Patients with Migraine and Sticky Platelet Syndrome.
Clin Appl Thromb Hemost
July 2025
Department of Hematology and Transfusiology, National Centre of Hemostasis and Thrombosis, Comenius University in Bratislava, Jessenius Faculty of Medicine and University Hospital in Martin, Martin, Slovakia.
One of the most common clinical manifestations of inherited platelet hyperaggregability also known as sticky platelet syndrome (SPS) is migraine. The aim of this study was to assess the role of single nucleotide polymorphisms (SNPs) of platelet endothelial aggregation receptor 1 () and murine retrovirus integration site 1 () genes in pathogenesis of SPS associated with migraine. Hundred patients with SPS and migraine as well as two hundred and seven patients with SPS and without migraine as a control group were enrolled.
View Article and Find Full Text PDFPrimary healthcare quality of migraine in China: a study using unannounced standardized patients.
Lancet Reg Health West Pac
June 2025
HEOA Group, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Background: Migraine, a highly prevalent headache disorder, is associated with several adverse health outcomes if not properly managed, but little is known about the quality of primary healthcare for migraine. This study aims to assess the quality of primary healthcare for migraine in China using the unannounced standardized patient (USP) method.
Methods: This cross-sectional study, conducted as part of the Primary Health Care Quality Cohort in China (ACACIA) from April 2021 to January 2023, involved 196 unannounced visits for migraine across seven provinces.
Complexities in Managing Psychosis in a Patient With Stiff-Person Syndrome: A Case Report.
Cureus
January 2024
School of Medicine, Touro College of Osteopathic Medicine, Middletown, USA.
Stiff-person syndrome (SPS) is an uncommon autoimmune neurological disorder marked by painful muscle stiffness, muscle spasms, and limb weakness. Neurological symptoms in SPS can mimic a psychogenic movement disorder in which symptoms are triggered by sudden movement and emotional distress, which might delay proper treatment. However, psychiatric symptoms are far less common, and there is limited understanding regarding the co-occurrence of psychiatric conditions.
View Article and Find Full Text PDFQuality in screening and measuring blood pressure in China's primary health care: a national cross-sectional study using unannounced standardized patients.
Lancet Reg Health West Pac
February 2024
Acacia Lab for Implementation Science, School of Health Management and Dermatology Hospital, Southern Medical University, Guangzhou, China.
Article Synopsis
- * Researchers used standardized patients to conduct 1201 visits across seven provinces, finding that less than one-third of patients had their blood pressure checked, often not following the recommended protocols.
- * The findings indicate a significant gap in hypertension screening practices in China, highlighting the need for better adherence to guidelines and improved training for healthcare providers.
A Rare Case Report of Neurological Condition: Moersch-Woltman Syndrome with Positive Anti-GAD Antibodies.
Int J Med Stud
September 2023
MBBS, Extern, Neurology Services Inc, Alexandria, Virginia, USA.
Background: Moersch-Woltman Syndrome (MWS), also known as Stiff person syndrome (SPS), is a rare, progressive condition of the central nervous system. Symptoms can include severe immobility, rigidity, and painful muscle spasms in the trunk and limbs. Muscle spasms can occur in MWS patients because they are more sensitive to noise, rapid movements, and mental disturbance.
View Article and Find Full Text PDF