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Purpose: This study investigates the charged particle fluence response of two reference ionization chambers (PTW T31021 Semiflex 3D and IBA CC04) and two silicon diode detectors (PTW microSilicon and IBA Razor diode) when measuring relative off-axis profiles in medium- to small-sized photon fields. Monte Carlo (MC) simulations are employed to determine the spectral fluence distribution of charged particles at different off-axis positions in water and within the investigated detectors. The goal is to enhance our understanding of the challenges associated with the dosimetry under non-equilibrium conditions and to calculate off-axis correction factors for the detectors under investigation.
Methods: Spectral fluence correction factors p were determined using a modified version of the EGSnrc user code egs_chamber. A standard linear accelerator model based on the Elekta Precise was used as beam source with a photon beam quality specifier TPR of 0.671. Field sizes as small as 0.5 cm ×0.5 cm were evaluated at a water depth of 10 cm.
Results: The analysis of spectral electron fluence in water as a function of off-axis positions across different field sizes revealed notable spectrum variations, particularly beyond the field edge and in the penumbra. These fluctuations directly impact the energy-dependent fluence response of the detectors. The assessment of p at the field edge demonstrated that the volume-averaging effect in air-filled ionization chambers is energy-dependent, with high-energy electron fluences being more strongly disturbed than low-energy fluences. In contrast, silicon diodes reproduced the relative profile within a 2% deviation but exhibited sensitivity to low-energy fluence fluctuations, especially in the penumbra.
Conclusion: The findings highlight the importance of selecting appropriate detectors for relative profile measurements and the necessity of applying detector-specific off-axis correction factors to account for variations in spectral electron fluence response.
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http://dx.doi.org/10.1016/j.zemedi.2025.06.004 | DOI Listing |
J Radiol Prot
September 2025
Department of Radiation Protection, Japan Atomic Energy Agency, Naka-gun, JAPAN.
In response to the new operational quantities proposed in ICRU Report 95, we calculated conversion coefficients for monoenergetic photon calibration fields-specifically, theAm γ-ray calibration field and the fluorescence X-ray calibration field-both of which are listed in the annex of the ISO 4037 standard series. These coefficients were derived using measured photon spectral fluence. Additionally, correction factors for air density were determined for the low-energy fluorescence X-ray calibration field.
View Article and Find Full Text PDFNanoscale Adv
August 2025
Institute of Ion Beam Physics and Materials Research, Helmholtz-Zentrum DresdenRossendorf 01328 Dresden Germany
Ion irradiation has routinely been used to create defects or even pattern two-dimensional (2D) materials. For efficient defect engineering, that is, choosing the proper ion fluence to achieve the desired concentration of defects, it is of paramount importance to know the probability of creating defects as a function of ion energy. Atomistic simulations of ion impacts on 2D targets can provide such information, especially for free-standing systems, but in the case of supported 2D materials, the substrate can strongly affect defect production.
View Article and Find Full Text PDFBiomedicines
August 2025
Department of Surgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
: Blue light (BL) irradiation has been shown to induce photobiomodulation (PBM) in cells. Here, we investigate its influence on cell types involved in wound healing. : Cellular responses of immortalized human keratinocytes (HaCaTs), normal human dermal fibroblasts (NHDFs), and human umbilical vein endothelial cells (HUVECs) after light treatment at 450 nm were analyzed by kinetic assays on cell viability, proliferation, ATP quantification, migration assay, and apoptosis assay.
View Article and Find Full Text PDFJ Biomed Opt
February 2025
University of New Mexico, Department of Neurology, School of Medicine, Albuquerque, New Mexico, United States.
Significance: Low-level near-infrared light-induced transcranial photobiomodulation (NIR-TPBM) is a promising technology for improving cerebral blood flow and metabolism. However, the effects of NIR-TPBM on the visual pathway's function remain poorly understood.
Aim: The aim was to assess the visual pathway's function changes in response to NIR-TPBM in young, healthy volunteers.
J Appl Clin Med Phys
September 2025
Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Background: Lack of an ideal detector for small field dosimetry has led to the development of many new types of detectors. Recent studies have shown that plastic scintillation detectors (PSDs) provide favorable dosimetric characteristics, such as minimal volume averaging and fluence perturbation effects, real time response rates, high signal to noise ratio (SNR), and independence to temperature, energy spectrum, dose rate, and irradiation direction, in the field of small field dosimetry, largely due to their small size and water-equivalent composition materials, which eliminates the need for certain correction factors.
Purpose: The goal of this study was to evaluate a new 0.