Assessing the Impact of Neuromuscular Taping on Thrombocyte Indices in Diabetic Neuropathy Patients With Peripheral Artery Disease: A Cross-Sectional Study.

Background And Aims: Peripheral artery disease (PAD) is a common complication among diabetic neuropathy patients, often associated with abnormalities in thrombocyte indices. This study aimed to assess the impact of neuromuscular taping (NMT) on thrombocyte indices in diabetic neuropathy patients with PAD.

Methods: A total of 23 patients diagnosed with DN using the Toronto Clinical Neuropathy Scoring System (TCNSS) and Diabetic Neuropathy Examination (DNE) were enrolled in the study. Participants underwent NMT decompression intervention sessions over a period of 24 days. Further, the genomic analysis utilized public databases derived from diabetes studies that investigated the development of diabetic neuropathy.

Results: The result revealed, pre- and post-intervention measurements demonstrated significant improvements in thrombocyte indices, particularly in platelet distribution width, platelet count, and mean platelet volume, among patients undergoing NMT ( < 0.05). Additionally, there was a notable decrease in TCNSS and DNE scores post-intervention, indicating an improvement in DN symptoms. Moreover, genomic analysis identified 9 genes, including SLC30A1, TRBJ2-7, OLFM1, TCF7L2, MCF2L, CEP295NL, CEACAM22P, TSHZ2, and PDZD4, involved in DN development.

Conclusion: These findings suggest that NMT holds promise as a therapeutic intervention for improving thrombocyte indices and managing DN symptoms in patients with PAD. Further research is warranted to elucidate the underlying mechanisms and long-term effects of NMT in this population.