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Verbal short-term memory (vSTM) draws on both phonological and lexical-semantic systems. This study examined whether vSTM support from semantic properties - specifically word imageability - varies with phonological ability and whether it endures rapid encoding conditions. Two auditory immediate serial recall (ISR) experiments tested recall for high - and low-imageability word lists in adults with and without developmental dyslexia. In Experiment 1, word imageability effects in standard presentation ISR were robust and equivalent across groups, despite the context of lower nonword recall in dyslexic participants. Experiment 2 used speeded presentation to limit rehearsal and reduce strategic encoding. Imageability effects were still observed, and a moderate association emerged between imageability benefit and nonword recall, which had not been observed with standard rate presentation. However, there remained no group-level differences in word recall. These findings indicate that imageability supports vSTM performance across individuals and task conditions. They do not provide strong evidence for compensatory mechanisms but rather highlight the general stability of semantic support in verbal memory across conditions.
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http://dx.doi.org/10.1080/09658211.2025.2536691 | DOI Listing |
J Control Release
August 2025
Lampe Joint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chap
HIV is a global health issue affecting approximately 40 million people worldwide, with low patient adherence being the primary challenge for maintaining effective pre-exposure prophylaxis (PrEP). Limitations of oral PrEP are mainly attributed to lack of adherence due to pill fatigue or stigma [1, 2]. Recently introduced long-acting injectables offer several advantages over daily PrEP, namely by improving adherence and improving efficacy [3-5].
View Article and Find Full Text PDFBrain
September 2025
Center for Brain Plasticity and Recovery, Departments of Neurology and Rehabilitation Medicine, Georgetown University Medical Center, Washington, DC 20057, USA.
Diagnosis of alexia has historically focused on syndromes such as surface alexia, which capture discrete patterns of reading deficits observed in some patients but do not describe the breadth of reading deficits observed in practice. Aphasia research has recently shifted focus to language process impairments rather than syndromic classifications. A similar shift in focus to reading process impairments might improve our diagnostic approach to alexia.
View Article and Find Full Text PDFCell Rep
August 2025
Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Hospital, Aachen, North Rhine-Westphalia (NRW) 52074, Germany; Center for Integrated Oncology Aachen (CIO(A)), RWTH Aachen University Hospital, Aachen, North Rhine-Westphalia (NRW
Targeting and treating metastatic cancer remain major clinical challenges. We developed an optically imageable metastatic mouse model based on near-infrared protein-expressing 4T1 triple-negative breast cancer cells. Using multimodal imaging, we studied the tumor and metastasis tropism of core-crosslinked polymeric micelles (CCPMs) as well as the antitumor and antimetastatic efficacy of clinical-stage docetaxel-loaded CCPMs (docetaxel-CCPMs).
View Article and Find Full Text PDFMemory
July 2025
School of Education, Language and Psychology, York St. John University, Lord Mayor's Walk, United Kingdom.
Verbal short-term memory (vSTM) draws on both phonological and lexical-semantic systems. This study examined whether vSTM support from semantic properties - specifically word imageability - varies with phonological ability and whether it endures rapid encoding conditions. Two auditory immediate serial recall (ISR) experiments tested recall for high - and low-imageability word lists in adults with and without developmental dyslexia.
View Article and Find Full Text PDFBackground: The 1p/19q co-deletion is a hallmark of oligodendrogliomas. The goal of this study was to exploit metabolic vulnerabilities induced by the 1p/19q co-deletion for oligodendroglioma therapy and non-invasive imaging.
Methods: We used stable isotope tracing, mass spectrometry, and genetic and pharmacological approaches to interrogate [U- C]-glucose metabolism in patient-derived oligodendroglioma models (SF10417, BT88, BT54, TS603, NCH612).