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Geoprocessing represents an essential methodology for the spatial and temporal monitoring of populations, playing a strategic role in the vector control of Chagas disease. This cross-sectional, ecological, and retrospective study analyzed the spatiotemporal distribution of triatomines in the State of Pará, Brazilian Amazon, between 1977 and 2024, based on records from the Evandro Chagas Institute. A total of 9593 triatomines were identified, classified into 11 species and 6 genera originating from 83 municipalities. Several species of medical importance were documented, notably Rhodnius pictipes, Rhodnius robustus, Panstrongylus geniculatus, Triatoma rubrofasciata, and Panstrongylus lignarius. Collection activities were more frequent during the second half of the year, coinciding with an increase in acute cases of Chagas disease in the state. The municipalities of Belém, Parauapebas, Barcarena, Muaná, and Abaetetuba accounted for 71.69 % of all records, while the highest infectivity rates were observed in São Francisco do Pará, Irituia, Cachoeira do Arari, Afuá, and Ananindeua. Human contact with the vector occurred predominantly in domestic environments, especially at night and most frequently in bedrooms, with Rhodnius pictipes, Panstrongylus geniculatus, and Triatoma rubrofasciata being the most commonly encountered species. Additionally, Rhodnius pictipes and Panstrongylus geniculatus exhibited the highest positivity rates for trypanosomatids. Consequently, Chagas disease remains endemic in the Amazon region, with Pará being one of the most affected states, mainly due to oral transmission associated with the consumption of açaí (Euterpe oleracea). This scenario is directly related to the region's triatomine fauna, whose dispersion is intensified by unregulated anthropogenic activities, highlighting the need for integrated vector surveillance and control strategies.
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http://dx.doi.org/10.1016/j.actatropica.2025.107733 | DOI Listing |
J Ultrasound Med
September 2025
Evandro Chagas Infectious Diseases National Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Objectives: The risk of major venous thromboembolism (VTE) among patients with COVID-19 is high but varies with disease severity. Estimate the incidence of lower extremity deep venous thrombosis (DVT) in critically ill hospitalized patients with COVID-19, validate the Wells score for DVT diagnosis, and determine patients' prognosis.
Methods: This was an observational follow-up study in the context of the diagnosis and prognosis of DVT.
Curr Fungal Infect Rep
April 2025
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, USA.
Purpose Of Review: This review summarizes current literature about the disability burden of the fungal neglected tropical diseases (NTDs) sporotrichosis, chromoblastomycosis, eumycetoma, and paracoccidioidomycosis. The review highlights current knowledge gaps in global settings and describes available tools that could be adopted to fill these gaps.
Recent Findings: Sporotrichosis, chromoblastomycosis, and eumycetoma often present initially as skin lesions that can become progressively disfiguring, lead to stigmatization, and cause various sequalae affecting health and function.
ChemMedChem
September 2025
Laboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Apartado 47206, Los Chaguaramos, Caracas, 1041-A, Venezuela.
Due to the advantages of drug repurposing, the discovery of new chemotherapeutic agents for the treatment of Chagas disease based on approved drugs has become a strategy for identifying new candidates. In this work, the antidepressant drug sertraline is reported, with an IC of 7.8 ± 1.
View Article and Find Full Text PDFJ Interv Card Electrophysiol
September 2025
Federal University of Minas Gerais, R. Alfredo Balena, 190, Santa Efigênia, Belo Horizonte, Brazil.
Background: Chagas heart disease (ChD) is a significant public health concern in Latin America, contributing to a high incidence of sudden cardiac death (SCD). Despite advances in heart failure treatment, management of Chagas cardiomyopathy has not progressed accordingly. While ICDs are effective for primary and secondary prevention in other conditions, patients with ChD often experience more frequent episodes of ventricular tachycardia, and ICD use may provide a negative impact and increase mortality.
View Article and Find Full Text PDFJ Pharm Pharmacol
September 2025
Facultad de Farmacia y Bioquímica, Departamento de Tecnología Farmacéutica, Cátedra de Tecnología Farmacéutica II, Universidad de Buenos Aires, C1113AAD Buenos Aires, Argentina.
Objectives: To develop the orphan drug benznidazole (BNZ) in orally disintegrating tablets, for the neglected disease American Trypanosomiasis (Chagas disease) therapy. Although children are highly affected by this disease, there are no specific commercial pharmaceutical preparations for this age group in Argentina and in many other countries.
Methods: In the production process, co-milling in a ball mill was applied to enhance dissolution rates, followed by direct compression.