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The purpose of this study was to investigate the antioxidant and antimicrobial activity of free and nanoencapsulated banana (BE) and apple (AE) peel extracts on the physicochemical, oxidative stability, antibacterial effect, and sensory characteristics of whipped cream during 28 days of cold storage at 4°C. BE and AE were nanoencapsulated in basil seed gum coating. The particle size, polydispersity index (PDI), and zeta potential of BE and AE-loaded nanoparticles was 116.5 and 112.2 nm, 0.296 and 0.248, -49.71 and -49.16 mV, respectively. Free extract and apple peel exhibited significantly higher ( < 0.05) antioxidant activity than encapsulated extract and banana extract. Encapsulated extract had higher antimicrobial activity against and . Free and nanoencapsulated extracts were added to whipped cream formulation at a constant level of 2% w/w. All nanocarriers had a spherical shape without aggregation. pH, apparent viscosity, overrun, drainage, color indexes, peroxide value, thiobarbituric acid, total microbial count, and sensory characteristics of whipped cream were examined. Nanocarriers improved the pH, apparent viscosity, hardness, overrun, oxidative stability, foam stability, and also significantly reduced the acidity, drainage, and microbial load of whipped cream samples during the cold storage period ( < 0.05). The antioxidant and antimicrobial activity of nanocarriers at the last days of storage was higher than unencapsulated BE and AE. AE showed a higher preservative effect than BE. All whipped cream samples containing extract had acceptable sensory scores. BE and AE, especially in encapsulated form, have remarkable antioxidant and antimicrobial activities and are able to improve the oxidative stability, antibacterial activity, and physicochemical characteristics of whipped cream. The results of this study suggested the use of 2% w/w of nanoencapsulated peel extract in the formulation of whipped cream.
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http://dx.doi.org/10.1002/fsn3.70652 | DOI Listing |
J Drug Deliv Sci Technol
November 2025
Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota, United States.
Panobinostat is a highly active and potent non-selective histone deacetylase inhibitor (HDACi) that demonstrates significant anticancer activity against various cancers, including pancreatic cancer. However, like other HDAC inhibitors, its anticancer efficacy is often limited due to factors such as hydrophobicity, non-specificity to tumor cells, and poor pharmacokinetics. To overcome these limitations, encapsulating panobinostat in nanocarriers can enhance controlled drug release and increase cellular uptake, thereby improving therapeutic efficacy.
View Article and Find Full Text PDFAdv Pharmacol Pharm Sci
August 2025
Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León (UANL), San Nicolás de los Garza 66450, Nuevo León, Mexico.
Lung cancer is the second most common type of cancer and the leading cause of cancer-related deaths worldwide. Some chemotherapeutic agents, such as curcumin and gemcitabine, have low bioavailability due to their hydrophobicity or the need for specialized transporters. This limits their cytotoxic potential against tumor cells but can be addressed through nanoencapsulation.
View Article and Find Full Text PDFFitoterapia
August 2025
College of Basic Medical Science, China Three Gorges University, Yichang 443002, China. Electronic address:
Tanshinones (TS), bioactive lipophilic diterpenoids derived from Salvia miltiorrhiza(SM), demonstrate significant therapeutic promise for acne vulgaris (AV)-a multifactorial dermatosis characterized by P.acnes colonization, aberrant follicular keratinization, and immune-inflammatory cascades exacerbated by endocrine dysregulation and psychosocial stressors. This comprehensive review synthesizes recent advances elucidating TS's tripartite mechanistic framework: (1) Direct antibacterial activity against P.
View Article and Find Full Text PDFAppl Microbiol Biotechnol
August 2025
Department of Nutrition Sciences, College of Health Sciences, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar.
The rise of antibiotic-resistant Salmonella in poultry poses a significant public health challenge. This study assessed the efficacy of carvacrol and trans-cinnamaldehyde, in free and nanoencapsulated forms, as natural alternatives to chlorine for inactivating antibiotic-resistant Salmonella in chicken. While several studies have evaluated free trans-cinnamaldehyde and carvacrol, there is a notable lack of research on encapsulated forms, using different types of capsules for controlled release of these antimicrobials in food applications.
View Article and Find Full Text PDFBiomed Pharmacother
August 2025
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Natural origin therapeutic agents have recently gained attention as a promising cancer treatment approach. However, achieving effective therapeutic results depends on improving the pharmacokinetic properties of these compounds using new delivery systems. In this study, the simultaneous encapsulation of berberine and hesperidin in poly(lactic-co-glycolic acid)(PLGA) nanoparticles utilizing the double emulsion-solvent evaporation technique and the evaluation of their effects on the viability and induction of apoptosis in prostate cancer cells were investigated.
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