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This study investigates how manufacturing defects transform the statistical distribution of failure in carbon fiber-reinforced polymer composites under tension and compression loading. The analysis of tension and compression specimens reveals that defect-free composites exhibit relatively narrow, unimodal strength distributions. In contrast, specimens with porosity or fiber waviness develop more complex multimodal probability densities with fat-tailed distributions and substantially higher variability. Applying Jensen's inequality demonstrates that this increased variability can be assessed to identify higher risk profiles. These findings indicate that defects in composites don't simply reduce mean strength values but alter the statistical nature of composite failure, transforming thin-tailed, unimodal, well-behaved distributions into multimodal, fat-tailed ones. Such transformation necessitates more sophisticated probabilistic approaches for reliable design and strength prediction in safety-critical applications where understanding tail risk becomes crucial to proper risk management.
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http://dx.doi.org/10.1038/s41598-025-06693-4 | DOI Listing |
J Craniofac Surg
September 2025
Department of Craniomaxillofacial Surgery, Peking Union Medical College, Chinese Academy of Medical Sciences, Plastic Surgery Hospital, Beijing, China.
Objective: We designed a new distractor pairing a bioabsorbable upper fixing plate fixed by bioabsorbable screws with a traditional titanium distractor to simplify the second surgery removing the distractor after mandibular distraction osteogenesis. The present study aims to evaluate its biomechanical properties using finite element method.
Materials And Methods: Ten computer-aided designed models simulating mandibles of 5 patients under 2 working conditions, the instance of distraction and mastication, were produced.
Phys Rev Lett
August 2025
Shanghai Jiao Tong University, Tsung-Dao Lee Institute, Key Laboratory of Artificial Structures and Quantum Control (Ministry of Education), School of Physics and Astronomy, Shanghai 200240, China.
While Andreev bound states (ABSs) have been realized in engineered superconducting junctions, their direct observation in normal metal-superconductor heterostructures-enabled by quantum confinement-remains experimentally elusive. Here, we report the detection of ABSs in ultrathin metallic islands (Bi, Ag, and SnTe) grown on the s-wave superconductor NbN. Using high-resolution scanning tunneling microscopy and spectroscopy, we clearly reveal in-gap ABSs with energies symmetric about the Fermi level.
View Article and Find Full Text PDFBioinformatics
September 2025
MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh United Kingdom.
Motivation: A genome-wide variant effect calibration method was recently developed under the guidelines of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP), following ClinGen recommendations for variant classification. While genome-wide approaches offer clinical utility, emerging evidence highlights the need for gene- and context-specific calibration to improve accuracy. Building on previous work, we have developed an algorithm tailored to converting functional scores from both multiplexed assays of variant effects (MAVEs) and computational variant effect predictors (VEPs) into ACMG/AMP evidence strengths.
View Article and Find Full Text PDFJ Magn Reson Imaging
September 2025
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Background: Parkinson's disease (PD) often presents with lateralized motor symptoms at onset, reflecting asymmetric degeneration of the substantia nigra (SN). Neuromelanin (NM) loss and iron accumulation are hallmarks of SN pathology in PD, but their spatial distribution and interrelationship in PD patients with right-sided (PDR) or left-sided (PDL) motor symptom onset remain unclear.
Purpose: To investigate the spatial vulnerability and interrelationship of NM and iron in the SN among PDR, PDL, and healthy controls (HCs) using MRI.
Small
September 2025
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Quasi-1D van der Waals materials have emerged as promising candidates for flexible electronic and thermoelectric applications due to their intrinsic anisotropy, narrow band gaps, and mechanical flexibility. Herein, MXSe (M = Nb, Ta, X = Pd, Pt) nanowires are studied to understand the bonding-directed growth mechanism. Bond valence sums and binding energy analyses reveal that weak X2-Se2 interactions perpendicular to the c-axis facilitate anisotropic growth.
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