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Continuous bladder irrigation (CBI) is a frequent postoperative urological procedure that continuously flushes the bladder with saline. Its main goal is to control gross hematuria (blood in urine) and prevent the formation of clots that can block urinary flow and extend hospital stays. Despite its widespread use, traditional CBI methods are flawed. Currently, there is no standardized or quantitative method to evaluate the severity of hematuria; instead, clinicians rely on subjective visual assessments, using imprecise color descriptors such as "rose" or "cherry red." Saline flow rates must also be adjusted manually, requiring frequent bedside monitoring to assess urine color, regulate inflow, and replace fluid bags. This labor-intensive and inconsistent process contributes to complications in roughly 50% of patients receiving CBI. While some research efforts have explored optical sensing or automated flow regulation, none have successfully delivered a comprehensive solution that combines measurement, automation, alerts, and a user interface in a system suitable for clinical use. To overcome these challenges, we created UroFlo: a smart, adaptive CBI platform designed to streamline and improve hematuria management. UroFlo integrates five essential features: 1) quantitative hematuria analysis; 2) automated inflow control; 3) real-time monitoring of supply and waste volumes; 4) automated caregiver notifications; and 5) an intuitive user interface. By combining objective data with automated decision-making and intel-ligent alerts, UroFlo reduces the need for constant supervision, ensures consistency across care teams, and improves patient outcomes. This system represents a significant advancement in CBI technology, setting a new benchmark for standardizing care and enhancing safety.
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http://dx.doi.org/10.1109/MPULS.2025.3572587 | DOI Listing |
PLoS One
September 2025
Department of Health Services Research, and CAPHRI School for Public Health and Primary Care, Aging and Long Term Care Maastricht, Maastricht, the Netherlands.
Background: Older patients presenting with nonspecific complaints (NSC) in the Emergency Department (ED) pose diagnostic challenges. The lack of clear symptoms leads to high misdiagnosis rates, extended hospital stays, and functional impairment. However, limited research exists on diagnostic test utilization for this population.
View Article and Find Full Text PDFDrug Dev Ind Pharm
September 2025
Department of Pharmaceutics, Mallige College of Pharmacy, Silvepura, Bangalore -560090.
ObjectivesThis review aims to explore gelling drug delivery systems with emphasis on formulation strategies, gelation mechanisms, administration routes, and therapeutic benefits. It also seeks to understand the role of different polymers in achieving optimal gelation and drug release profiles. Additionally, the review aims to identify current research gaps and highlight potential areas for future development and clinical translation.
View Article and Find Full Text PDFNon-muscle-invasive bladder cancer (NMIBC) is common and heterogeneous, requiring risk-adapted therapeutic strategies. BCG remains standard for intermediate- and high-risk forms, but its effectiveness is influenced by limited access, variable tolerance, treatment resistance, and healthcare system disruptions. Material and This retrospective study aimed to identify prognostic factors for survival with an additional assessment of the influence of the COVID-19 pandemic.
View Article and Find Full Text PDFBiology (Basel)
July 2025
Institute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria.
Spinal cord injury (SCI) frequently leads to neurogenic lower urinary tract dysfunction, for which appropriate bladder management is essential. While clinical care relies on continuous low-pressure drainage in the acute phase, rat models commonly use twice-daily manual bladder expression-a method known to generate high intravesical pressures and retention. This study evaluated the impact of this standard practice on bladder tissue remodeling by comparing it to continuous drainage via high vesicostomy in a rat SCI model.
View Article and Find Full Text PDFAJR Am J Roentgenol
September 2025
Department of Radiology, NYU Langone Health, New York, NY (H.A.V.).
Since its introduction in 2018, the Vesical Imaging Reporting and Data System (VI-RADS) has emerged as a standardized and reproducible framework for multiparametric MRI assessment of bladder cancer, with validated diagnostic accuracy in distinguishing muscle-invasive from non-muscle-invasive disease. Despite growing international interest, expert consensus, and the system's inclusion in most major guidelines, real-world clinical adoption of VI-RADS remains limited. This AJR Expert Panel Narrative Review explores the key barriers that hinder the implementation of VI-RADS into everyday workflows across diverse healthcare settings, including skepticism among referring clinicians, an inability (unlike cystoscopy-based staging) to perform simultaneous tumor resection, suboptimal posttreatment performance, and variability in image quality and reader experience.
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