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Introduction: Diabetic foot ulcers (DFUs) are a common and serious complication of diabetes mellitus, often leading to prolonged morbidity and limb amputation. Successful management involves early debridement, infection control, and appropriate soft tissue coverage.
Methods: The present study is a retrospective case series conducted from March 1 to August 31, 2024, involving seven patients with chronic DFUs at Sree Balaji Medical College and Hospital. Each case underwent individualized reconstruction strategies, including split-thickness skin grafts (STSGs), reverse sural artery flaps, medial plantar artery flaps, cross-leg flaps, and conservative healing, depending on wound location, depth, and vascular status.
Results: All patients demonstrated favorable outcomes in terms of graft/flap viability and wound healing. Functional recovery was satisfactory in each case. No major complications or recurrences were observed during follow-up.
Conclusion: Early and tailored multimodal reconstructive approaches yield positive outcomes in DFUs. Strategic planning based on anatomical site and biomechanical load is crucial for effective limb salvage.
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http://dx.doi.org/10.7759/cureus.86013 | DOI Listing |
Front Endocrinol (Lausanne)
September 2025
Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Background: Diabetic foot ulcers (DFU) are a prevalent complication of diabetes, leading to significant morbidity, mortality, and amputation rates. Chronic non-healing DFU often result from peripheral neuropathy, microvascular issues, and infection, with poor blood and oxygen supply being critical factors in delayed healing. The development of new treatments to promote blood supply and accelerate ulcer healing is a significant area of research for DFU management.
View Article and Find Full Text PDFTurkiye Parazitol Derg
September 2025
Fırat University Faculty of Fisheries, Department of Aquaculture and Fish Diseases, Elazığ, Türkiye.
Objective: Hirudotherapy (HT), the therapeutic use of medicinal leeches, has been practised for centuries, and the interest in modern medicine has recently been renewed. This study evaluates the clinical outcomes of HT at Herba Medical Center in Azerbaijan between 2020 and 2024, focusing on its efficacy across 11 medical conditions.
Methods: A total of 181 patients were treated using disposable medicinal leeches () sourced from hygienic farms approved by Azerbaijan's Ministry of Ecology and Natural Resources.
Foot Ankle Int
September 2025
Department of Orthopaedic Surgery and Rehabilitation and Department of Vascular and Endovascular Surgery, Atrium Health Wake Forest Baptist Medical Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: The Infectious Diseases Society of America guidelines recommend a prolonged course of antibiotics in the setting of residual osteomyelitis. More recently published literature suggests that oral antibiotics may offer comparable outcomes to intravenously administered antibiotics when treating orthopaedic infections. In a prior study, we investigated the outcomes of both routes of antibiotic administration in patients with diabetic foot infections at a single academic medical institution.
View Article and Find Full Text PDFSemin Vasc Surg
September 2025
Division of Vascular and Endovascular Surgery, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY; Comprehensive Wound Care Healing and Hyperbaric, Department of Surgery, Northwell Health System, 270-05 76(th) Avenue, New Hyde Park, NY 11040. Electronic address:
Nonhealing wounds are increasingly prevalent, present in 1% to 2% of the global population, with higher incidence in geriatric patients. These chronic wounds pose challenges to older adult patients owing to physiologic changes that hinder healing, common medical comorbidities that promote inflammation and damage microcirculation, poor nutritional status and mobility, and psychosocial barriers to receiving care. In this literature review, the epidemiology, pathophysiology, systems costs, and management of chronic venous leg ulcers, arterial ulcers, and diabetic foot wounds in older adult patients are investigated.
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