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Article Abstract
We introduce a dual-purpose solvatochromic naphthalimide-benzothiazinone (BTZ) conjugate with theranostic potential that enables specific and rapid detection of by targeting the DprE1 enzyme, while also exhibiting antimicrobial activity. The photoinduced electron transfer (PeT)-based fluorophore incorporates into the mycobacterial cell wall, producing detectable fluorescence within 15 minutes and thus, highlighting its suitability for rapid, point-of-care TB detection in low-resource settings.
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