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Calcific diskitis (CD) is a rare condition characterized by inflammation and calcification of an intervertebral disk, typically causing localized back pain. We present the case of a 65-y-old woman with a history of breast cancer and persistent back pain. SPECT/CT identified focal uptake at the T10-T11 vertebrae, localized to the intervertebral disk. Retrospective review of MR images from 2016 demonstrated a hypointense signal within the same disk on both T1- and T2-weighted images, consistent with disk calcification. This case highlights the utility of SPECT/CT in identifying CD and distinguishing it from other pathologies, including metastatic or degenerative spinal disease. CD should be considered in the differential diagnoses of backache.
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http://dx.doi.org/10.2967/jnmt.124.268823 | DOI Listing |
J Small Anim Pract
September 2025
Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover, Germany.
Objectives: A thorough understanding of common practice patterns in a particular specialty can help identify and design new interventions to improve care delivery and access to care. The goals of this study were to document current practice patterns among veterinary "neurologists" and small animal "surgeons" in the surgical management of acute canine thoracolumbar intervertebral disc extrusion, to compare approaches between these two groups and to discuss current results compared to those published in 2016.
Materials And Methods: A web-based survey was distributed in October 2024 to collect responses from board-certified and regionally recognised neurology and surgery specialists in North America and Europe.
J Inflamm Res
September 2025
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Introduction: While nucleus pulposus cell (NPC) degeneration is a primary driver of intervertebral disc degeneration (IVDD), the cellular heterogeneity and molecular interactions underlying NPC degeneration remain poorly characterized. Previous studies have shown that EGFR signaling plays a significant role in NPC differentiation and collagen matrix production. Consequently, this study aims to identify the critical downstream regulatory molecule of EGFR in the process of NPC degeneration.
View Article and Find Full Text PDFAdv Healthc Mater
September 2025
Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.
Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP), significantly affecting on global disability and healthcare costs. Traditional treatments primarily focus on symptom management rather than addressing the underlying causes, such as the decline in nucleus pulposus (NP) cells and reduced extracellular matrix (ECM) synthesis. Cell therapy shows promise by replenishing NP cells, activating resident cells, and enhancing ECM deposition.
View Article and Find Full Text PDFBackground: Intervertebral disc degeneration (IDD) is a prevalent spinal condition frequently associated with pain and motor impairment, imposing a substantial burden on quality of life. Despite extensive investigations into the genetic predisposition to IDD, the precise pathogenic genes and molecular pathways involved remain inadequately characterized, underscoring the need for continued research to clarify its genetic underpinnings.
Methods: This study leveraged IDD data from the FinnGen R12 cohort and integrated expression quantitative trait loci data across 49 tissues from the Genotype-Tissue Expression version 8 database to perform a cross-tissue transcriptome-wide association study (TWAS).
Medicine (Baltimore)
September 2025
The Third School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Lower back pain caused by intervertebral disk degeneration (IDD) is a common problem among middle-aged and older adults. We aimed to identify novel diagnostic biomarkers of IDD and analyze the potential association between key genes and immune cell infiltration. We screened differentially expressed genes (DEGs) related to IDD and gene sets associated with mitochondrial energy metabolism using the Gene Expression Omnibus and GeneCards databases, respectively.
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