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As monkeypox is spreading rapidly, the incidence of monkeypox has been increasing in recent times. Therefore, it is very important to detect and diagnose this disease to get effective treatment planning. The prominent aim of this paper is to design an effective monkeypox detection and classification model by utilizing deep learning and classification models. In this study, a novel Adaptive Generative 3D VNet model is presented to effectively classify the monkeypox lesions. Different data augmentation approaches, deep learning, and adaptive fusion are integrated into the proposed model to attain better results in disease classification. The major objective of the proposed model is to mitigate the challenges of limited labeled data by generating synthetic augmented images and combining them with real images for robust classification. The two major components of the proposed system are the Adaptive Generative Network and the 3D VNet. Additional training models are generated by the adaptive generative network through augmentation approaches including cropping, rotation, and flipping, thereby increasing the diversity of the dataset. The 3D VNet processes these images in a volumetric manner to capture spatial relationships within the lesions, improving classification accuracy. The fusion layer then adaptively combines the predictions from the real and augmented data to optimize the overall effectiveness of a model. Key performance metrics including accuracy, precision, sensitivity, specificity, Jaccard Index, Hausdorff distance, and Dice Similarity Coefficient are used to compute the effectiveness of a model. The findings show that the Adaptive Generative 3D VNet model outperforms traditional 2D models by significantly improving the classification accuracy and robustness, especially in the presence of limited labeled data. Therefore, the simulation results demonstrate that the proposed model achieves high accuracy and precision of 98.8% and 98.5%, respectively based on the Monkeypox Skin Lesion Dataset.
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http://dx.doi.org/10.1007/s10278-025-01594-4 | DOI Listing |
Biom J
October 2025
Novella Clinical Full Service, IQVIA, Melbourne, Australia.
Phase I dose escalation trials in oncology generally aim to find the maximum tolerated dose. However, with the advent of molecular-targeted therapies and antibody drug conjugates, dose-limiting toxicities are less frequently observed, giving rise to the concept of optimal biological dose (OBD), which considers both efficacy and toxicity. The estimand framework presented in the addendum of the ICH E9(R1) guidelines strengthens the dialogue between different stakeholders by bringing in greater clarity in the clinical trial objectives and by providing alignment between the targeted estimand under consideration and the statistical analysis methods.
View Article and Find Full Text PDFJ Imaging Inform Med
September 2025
Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Large language models (LLMs) have been successfully used for data extraction from free-text radiology reports. Most current studies were conducted with LLMs accessed via an application programming interface (API). We evaluated the feasibility of using open-source LLMs, deployed on limited local hardware resources for data extraction from free-text mammography reports, using a common data element (CDE)-based structure.
View Article and Find Full Text PDFCell Death Differ
September 2025
Graduate Institute of Physiology, College of Biomedical Sciences, National Defense Medical University, Taipei, Taiwan, Republic of China.
Peroxisome proliferator-activated receptor alpha (PPARα) is a crucial transcriptional factor that regulates fatty acid β-oxidation and ketogenesis in response to fasting. However, the mechanisms underlying PPARα function remain unclear. This study identified a novel PPARα-binding protein-RING finger protein 128 (RNF128)-that facilitates PPARα polyubiquitination, resulting in the degradation and suppression of PPARα function during fasting.
View Article and Find Full Text PDFNature
September 2025
School of Earth Sciences, University of Bristol, Bristol, UK.
The Lepidosauria is the most species-rich group of land-dwelling vertebrates. The group includes around 12,000 species of lizards and snakes (Squamata) and one species of Rhynchocephalia, the tuatara Sphenodon punctatus from New Zealand. Squamates owe their success to their generally small size, but also to their highly mobile skull that enables them to manipulate large prey.
View Article and Find Full Text PDFCommun Biol
September 2025
Department of General and Applied Biology, São Paulo State University (UNESP), Institute of Bioscience, Rio Claro, SP, Brazil.
Symbiotic relationships shape the evolution of organisms. Fungi in the genus Escovopsis share an evolutionary history with the fungus-growing "attine" ant system and are only found in association with these social insects. Despite this close relationship, there are key aspects of Escovopsis evolution that remain poorly understood.
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