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In the behavior of concrete, factors such as particle types, water content, aggregates, additives, and binders significantly influence its Compressive Strength (CS) properties. This study develops hybrid and ensemble models to predict compressive CS and slump flow of high-performance concrete (HPC) using a dataset of 191 mixtures. Admixtures like fly ash and silica fume enhance HPC through hydraulic or pozzolanic activity. Understanding the relationships between HPC components is crucial for computational analysis of CS properties. Deep learning techniques, including hybrid and ensemble methods, were developed to predict these properties with high accuracy. This paper focuses on forecasting models using T-SFIS, GBMBoost, and Decision Tree, combined with metaheuristic algorithms (GWO, QPSO) in hybrid and ensemble frameworks. Sensitivity analysis via SHAP and tenfold cross-validation evaluated model performance. Results showed that the GWO-based GBQP model achieved superior performance ([Formula: see text]=0.998, RMSE = 1.216 MPa for compressive CS). The ensemble DGT model ranked second, while T-SFIS performed lowest. For slump flow, TSQP excelled ([Formula: see text]=0.984, RMSE = 3.233 mm), closely followed by GBQP. These advanced techniques significantly enhance the efficiency and accuracy of predicting HPC CS properties.
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http://dx.doi.org/10.1038/s41598-025-10860-y | DOI Listing |
PLoS One
September 2025
School of Computer Science, CHART Laboratory, University of Nottingham, Nottingham, United Kingdom.
Background And Objective: Male fertility assessment through sperm morphology analysis remains a critical component of reproductive health evaluation, as abnormal sperm morphology is strongly correlated with reduced fertility rates and poor assisted reproductive technology outcomes. Traditional manual analysis performed by embryologists is time-intensive, subjective, and prone to significant inter-observer variability, with studies reporting up to 40% disagreement between expert evaluators. This research presents a novel deep learning framework combining Convolutional Block Attention Module (CBAM) with ResNet50 architecture and advanced deep feature engineering (DFE) techniques for automated, objective sperm morphology classification.
View Article and Find Full Text PDFBiophys J
September 2025
Biophysical and Biomedical Measurement Group, Microsystems and Nanotechnology Division, Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA. Electronic address:
Macromolecular structure is central to biology. Yet, not all biomolecules have a well-defined fold. Intrinsically disordered regions are ubiquitous, conveying a versatility to function even in otherwise folded structures.
View Article and Find Full Text PDFJ Dairy Sci
September 2025
Advance Image Processing Research Laboratory (AIPRL), Institute of Computer and Software Engineering, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan 64200, Pakistan.
Food contamination remains a serious global concern due to its health risks, with milk being one of the most commonly adulterated foods in developing countries such as Pakistan, India, and Bangladesh. Accurate detection of milk contamination is essential for ensuring consumer safety and maintaining food industry standards. This study explores both invasive and noninvasive approaches for contamination analysis.
View Article and Find Full Text PDFJ Chem Inf Model
September 2025
Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, U.K.
We present the protolysis-targeting chimera (PROTAC) Conformer Generator, a fast and knowledge-based tool for generating robust conformational ensembles of PROTACs and other chimeric degraders. The modeling protocol integrates conformer generation, rigid-body ternary complex (TC) assembly, and conformational sampling strategies that address the inherent flexibility and complexity of these molecules. Each modeled TC is evaluated using a clash-score and a surface-score, designed to prioritize sterically and geometrically plausible models with favorable protein surface interactions.
View Article and Find Full Text PDFJ Biomed Phys Eng
August 2025
Department of Biomedical Systems & Medical Physics, Tehran University of Medical Sciences, Tehran, Iran.
Background: Wireless Capsule Endoscopy (WCE) is the gold standard for painless and sedation-free visualization of the Gastrointestinal (GI) tract. However, reviewing WCE video files, which often exceed 60,000 frames, can be labor-intensive and may result in overlooking critical frames. A proficient diagnostic system should offer gastroenterologists high sensitivity and Negative Predictive Value (NPV) to enhance diagnostic accuracy.
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