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Article Abstract
Pd-catalyzed enol-directed cascade C-H functionalization and annulation of 2-aryl-1,3-dicarbonyls have been developed using vinylcyclopropanes as a coupling partner. Utilization of an intrinsic weak chelating group, C-C/C-O bond formation, substrate scope, functional group tolerance, subsequent hydrogenolysis, and hydrogenation of products to furnish alkylated 2-aryl-1,3-dicarbonyls and late-stage product modifications are the important practical features.
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| http://dx.doi.org/10.1021/acs.orglett.5c02216 | DOI Listing |
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