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Article Abstract

Introduction And Importance: Calcific myonecrosis is a rare entity characterized by coagulative and liquefactive necrosis with calcifications of the entire muscle mass of the involved compartment secondary to post-traumatic compartment syndrome. There is limited literature on the rare disease with technical difficulties and pitfalls of operative procedures in these patients.

Presentation Of Case: A 52-year-old male presented with complaints of swelling over his right leg with discharging sinus over the past 2 years following a surgical intervention. He was diagnosed as a case of calcific myonecrosis based on history and clinico-radio-histological correlation and was managed successfully with en bloc excision with vacuum-assisted closure (VAC) of wound.

Clinical Discussion: A rare musculoskeletal condition is characterized by muscle necrosis and extensive calcification within a limb compartment, typically following post-traumatic compartment syndrome involving muscle and neurovascular structures. Diagnosis relies heavily on radiological findings, such as calcifications and adjacent bone erosions, while histopathology is crucial to exclude malignancy. A high index of clinical suspicion is essential for timely identification.

Conclusion: Calcific myonecrosis requires a multi-factorial approach to reach to a diagnosis, with ruling out the differentials and proper preoperative plan are the key to success. If un-infected, it is a "Touch me not disease"; however, through debridement or en-mass excision of compartment with VAC therapy should be considered for infected cases.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254451PMC
http://dx.doi.org/10.1007/s43465-025-01428-zDOI Listing

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Introduction And Importance: Calcific myonecrosis is a rare entity characterized by coagulative and liquefactive necrosis with calcifications of the entire muscle mass of the involved compartment secondary to post-traumatic compartment syndrome. There is limited literature on the rare disease with technical difficulties and pitfalls of operative procedures in these patients.

Presentation Of Case: A 52-year-old male presented with complaints of swelling over his right leg with discharging sinus over the past 2 years following a surgical intervention.

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Calcific myonecrosis: Report of 4 cases and review.

Radiol Case Rep

July 2025

Department of Orthopedic Surgery, Musculoskeletal Oncology Unit, Rambam Health Care Campus, Haifa 3109601, Israel.

Calcific myonecrosis presents as a rare, late complication stemming from trauma or a neurovascular injury, predominantly affecting the lower limb. It manifests as a progressively enlarging, painful, dystrophic calcified mass, often following compartment syndrome and vascular or neurological compromise, leading to necrosis and fibrosis. While its radiological appearance is typically distinctive, biopsy is commonly pursued due to concerns of malignancy (as calcific myonecrosis may resemble soft tissue sarcoma), often resulting in superimposed infections.

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Article Synopsis
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 Calcific myonecrosis (CM), a rare post-traumatic sequel of the lower limb, is characterized by calcified lesions. A diagnosis of CM can be difficult owing to the longtime span from the emergence of the original trauma to the onset of the symptoms of CM. This case report aimed to feature a case of a 55-year-old gentleman who presented with a progressive painful swelling in the anterolateral aspect of the right lower leg with the initial trauma arising 11 years ago.

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