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Article Abstract
Significance: Compensation for depth-dependent fluence without knowledge of tissue composition is a crucial unmet need for quantitative photoacoustic imaging.
Aim: We developed a method for estimating the effective optical attenuation coefficient of bulk tissue with composition and optical properties that are not known in advance, through combined ultrasound/photoacoustic imaging during mechanical displacement of tissue.
Approach: Ultrasound/photoacoustic imaging was performed on a target embedded in biological media while applying tissue displacement to change the optical path. After compensation for geometry-dependent scattering of light from light source apertures, the change of photoacoustic amplitude against optical path length was used to estimate the effective optical attenuation coefficient.
Results: Using the developed approach, the estimation of the effective optical attenuation coefficient of tissue-mimicking (milk/water) phantoms and porcine muscle and chicken breast was accurate compared with ground-truth literature values.
Conclusions: Regardless of the varying geometries used for light delivery in photoacoustic imaging, it is feasible to perform ultrasound-guided photoacoustic imaging with simultaneous mechanical displacement of tissue to determine the effective optical attenuation coefficient of bulk tissue along the light path to the target.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255355 | PMC |
| http://dx.doi.org/10.1117/1.JBO.30.7.076005 | DOI Listing |
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