Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Quercetin (Qu), a naturally occurring flavonoid with potent antioxidant, anti-inflammatory, and anticancer properties, faces clinical limitations due to poor solubility, low stability, and suboptimal bioavailability. This review comprehensively explores nano-quercetin (nano-Qu) formulations as a transformative solution, focusing on material design, synthesis strategies, and biomedical applications. A comprehensive review of diverse nanocarriers, including lipid-based, inorganic, polymeric, and composite nanoparticles, is presented to systematically evaluate their potential in improving solubility, stability, and targeted drug delivery of Qu. Advanced synthesis techniques such as chemical conjugation, self-assembly, and physical encapsulation are evaluated for optimizing drug loading and controlled release. Preclinical studies highlight nano-Qu's efficacy in cancer therapy, inflammatory disorders, metabolic diseases, and tissue regeneration, attributed to improved pharmacokinetics and target-specific mechanisms. Despite promising advancements, challenges in biocompatibility, long-term toxicity, and scalable production require further investigation. This work underscores the potential of nanotechnology to unlock Qu's therapeutic versatility.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239925 | PMC |
| http://dx.doi.org/10.2147/IJN.S517079 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Emerging strategies, applications and challenges of targeting NAD in the clinic.
Nat Aging
September 2025
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Beyond their classical functions as redox cofactors, recent fundamental and clinical research has expanded our understanding of the diverse roles of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in signaling pathways, epigenetic regulation and energy homeostasis. Moreover, NAD and NADP influence numerous diseases as well as the processes of aging, and are emerging as targets for clinical intervention. Here, we summarize safety, bioavailability and efficacy data from NAD-related clinical trials, focusing on aging and neurodegenerative diseases.
View Article and Find Full Text PDFBeyond Hemoglobin: A Review of Hemocyanin and the Biology of Purple Blood.
Zhongguo Ying Yong Sheng Li Xue Za Zhi
September 2025
PSIT-Pranveer Singh Institute of Technology (Pharmacy), Kanpur - Agra - Delhi, NH#2, Bhauti, Kanpur, Uttar Pradesh, India.
Hemocyanin is dissolved freely in hemolymph, the invertebrate blood substitute, in contrast to haemoglobin, which is encased in red blood cells. When oxygenated, this pigment gives mollusc and arthropod blood its characteristic blue or purple hue. This review article delves into the fascinating biology of hemocyanin, the copper-based oxygen-carrying protein responsible for "purple blood" in many invertebrates, contrasting its characteristics with the more familiar iron-based hemoglobin.
View Article and Find Full Text PDFCrowdsourcing a Training Dataset of Question-and-Answer Pairs for AI-Enabled Health Information Tools on Sexually Transmitted Infections: Protocol for a Cross-Sectional Exploratory Survey Study.
JMIR Res Protoc
September 2025
Academy for Health Innovation Uganda, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Background: Sexually transmitted infections are a significant public health concern, particularly in sub-Saharan Africa, where their prevalence remains high. Promoting awareness and reducing stigma are essential strategies for addressing this challenge, but those affected often have limited access to accurate and culturally appropriate health information. Therefore, innovative solutions are essential to enhance sexual health literacy and encourage informed health-seeking behaviors.
View Article and Find Full Text PDFAptamers as target-specific recognition elements in drug delivery.
Adv Drug Deliv Rev
September 2025
Biochemistry, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States; Molecular, Cellular, and Developmental Biology, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States; Chemistry, CUNY Gradua
Targeted drug delivery significantly enhances therapeutic efficacy across various diseases, particularly in cancer treatments, where conventional approaches such as chemotherapy and radiotherapy often cause severe side effects. In this context, nucleic acid aptamers-short, single-stranded DNA or RNA oligonucleotides capable of binding specific targets with high affinity-have emerged as promising tools for precision drug delivery and therapy. Aptamers can be selected against whole, living cells using SELEX and chemically modified for diverse applications.
View Article and Find Full Text PDFAn adjustable three-layer skull phantom with realistic ultrasound transmission properties.
Phys Med Biol
September 2025
Zhejiang University, Zijingang Campus of Zhejiang University,Yuhangtang Road No.866,Zhejiang Province, China 310058, Hangzhou, Zhejiang, 310058, CHINA.
Transcranial ultrasound research has garnered significant attention due to its non-invasive nature, absence of ionizing radiation, and portability, making it advantageous for both imaging and therapy. A critical aspect of advancing transcranial research lies in understanding the ultrasound transmission performance of the human skull. However, inherent variations in skull shape, physical parameters, and age-related changes pose challenges for comparative studies.
View Article and Find Full Text PDF