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Background Context: Postoperative urinary retention (POUR) is a common complication following spinal surgery, increasing patient morbidity through prolonged hospital stays and urinary infections. Traditional diagnostic criteria, relying on two consecutives postvoid residual (PVR) volumes of 300 mL, may fail to predict delayed POUR in cases with initial PVR below this threshold.
Purpose: This study aims to establish refined PVR cut-off values that can predict delayed POUR in spinal surgery patients, incorporating stratified thresholds based on identified risk factors such as gender and age. By defining these specific thresholds, the study seeks to enhance postoperative voiding care protocols and improve clinical decision-making regarding the need for continued urinary monitoring.
Study Design: Retrospective, single-center cohort study.
Patient Sample: This study included 310 patients aged 18 years or older who underwent elective thoracolumbar spinal surgery with intraoperative Foley catheterization between January 2021 and December 2023.
Outcome Measures: The primary outcome was the occurrence of delayed POUR, defined as PVR exceeding 300 mL after postoperative voiding care protocols concluded.
Methods: All patients underwent bladder scan after Foley catheter removal to measure PVR volumes. Multivariable logistic regression analyses were used to identify risk factors of POUR. Receiver operating characteristic (ROC) curve analysis was conducted to determine optimal PVR thresholds for delayed POUR stratified by gender, age, surgical levels, and ADS score.
Results: Delayed POUR occurred in 38 patients (11.9%) and was significantly associated with older age (≥75 years: OR 3.02, 95% CI 1.32-6.94, p=.009), higher initial PVR per 100 mL (OR 2.96, 95% CI 1.77-4.96, p<.001), and Anticholinergic drug score (ADS) ≥ 2 (OR 2.57, 95% CI 1.06-6.28, p=.038). ROC analysis identified optimal PVR thresholds for predicting delayed POUR: 61 mL for male patients (AUC=0.68) and 101 mL for female patients (AUC=0.77). Further subgroup analysis revealed lower cut-off values for patients at higher risk, such as those with multiple surgical levels or ACS ≥ 2.
Conclusions: This study establishes refined PVR cut-off values for predicting delayed POUR in spinal surgery patients, offering a stratified approach based on patient-specific factors. These findings support a shift toward personalized postoperative voiding care protocols, improving early detection and intervention to prevent complications associated with urinary retention.
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http://dx.doi.org/10.1016/j.spinee.2025.07.003 | DOI Listing |
J Autism Dev Disord
September 2025
Université Paris Cité, LPPS, F-92100, Boulogne-Billancourt, France.
Parents of adults with autism spectrum disorders (ASD) face significant challenges, including high vulnerability to stress and a lack of adequate support services. However, there are currently few support systems based on a genuine assessment of their needs. This is particularly true in the French context, where there are delays in supporting families and addressing autism in adulthood.
View Article and Find Full Text PDFDis Model Mech
August 2025
Institute of Human Genetics, Heidelberg University Clinic, Heidelberg, Germany.
Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS) is a rare, autosomal dominant neurodevelopmental disorder caused by pathogenic variants in NR2F1, characterized by developmental delay, intellectual disability, optic nerve anomalies, and autism spectrum disorder. Most pathogenic variants cluster within the highly conserved DNA-binding domain (DBD) or ligand-binding domain (LBD) of NR2F1 and are associated with variable clinical severity, suggesting a genotype-phenotype correlation. While previous mouse models have provided important insights, comprehensive behavioral characterization remains limited.
View Article and Find Full Text PDFNat Commun
August 2025
Univ Rouen Normandie, INSERM NorDiC UMR 1239, Rouen, France.
Non-small cell lung cancers (NSCLCs) treated with tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) almost invariably relapse in the long term, due to the emergence of subpopulations of resistant cells. Through a DNA barcoding approach, we show that the clinically approved drug sorafenib specifically abolishes the selective advantage of EGFR-TKI-resistant cells, while preserving the response of EGFR-TKI-sensitive cells. Sorafenib is active against multiple mechanisms of resistance/tolerance to EGFR-TKIs and its effects depend on early inhibition of MAPK-interacting kinase (MKNK) activity and signal transducer and activator of transcription 3 (STAT3) phosphorylation, and later down-regulation of MCL1 and EGFR.
View Article and Find Full Text PDFBlood Adv
August 2025
Department of Medicine, Korea University, Seoul, Republic of Korea, Athens, Greece.
Belantamab mafodotin (belamaf) combined with standard therapies demonstrated significant progression-free survival (PFS) and overall survival benefits in DREAMM-7 and PFS benefit in DREAMM-8 in relapsed/refractory multiple myeloma. Belamaf dose modifications managed adverse events, including belamaf-related ocular events. Ocular events included ocular adverse reactions (eg, dry eyes, photophobia, eye irritation) and protocol-mandated ophthalmic examination findings.
View Article and Find Full Text PDFAnn Chir Plast Esthet
July 2025
Service de chirurgie plastique, esthétique et reconstructrice, hôpital Saint-Joseph Saint-Luc, 20, quai Claude-Bernard, 69007 Lyon, France.
Introduction: Although surgical site infection is one of the classic complications of breast reduction surgery, since 2024 the Société française d'anesthésie réanimation (SFAR) no longer recommends the administration of preoperative antibiotic prophylaxis. This study presents the evolution of postoperative breast infection rates in our unit according to the application of this recommendation, by comparing surgical site infection rates between homogeneous groups of patients: with and without antibiotic prophylaxis.
Methods: This was a retrospective, single-center, comparative study.