Visible-Light-Induced Catalyst-Free Three-Component Reaction of α-Hydroxy Ketones, Styrenes, and 4-Cyanopyridine.

Chemistry

The State Key Laboratory of Natural Product Chemistry, and the College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui Road, Lanzhou, 730000, People's Republic of China.

Published: August 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

A visible-light-induced, transition-metal- and photosensitizer-free three-component acylpyridylation of styrenes is presented. In this strategy, α-hydroxy ketones play a triple role: they act as visible-light-activated photosensitizers, acylation reagents, and reductants. This approach does not require transition-metals, external photosensitizers, or reductive reagent, demonstrating high efficiency, mild reaction conditions, and robust tolerance to various functional groups.

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.202501191DOI Listing

Publication Analysis

Top Keywords

α-hydroxy ketones
8
visible-light-induced catalyst-free
4
catalyst-free three-component
4
three-component reaction
4
reaction α-hydroxy
4
ketones styrenes
4
styrenes 4-cyanopyridine
4
4-cyanopyridine visible-light-induced
4
visible-light-induced transition-metal-
4
transition-metal- photosensitizer-free
4

Similar Publications