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Article Abstract
Chromatin domain boundaries are crucial for development by spatially constraining enhancer activity to ensure precise spatiotemporal gene regulation. In this issue of Developmental Cell, Chakraborty et al. demonstrate that the loss of a chromatin domain boundary caused by deletion of a single CTCF motif can lead to severe developmental defects.
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| http://dx.doi.org/10.1016/j.devcel.2025.05.005 | DOI Listing |
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