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Morphological anisotropies and nonlinear mechanical properties shape the kinematic agility of organisms and engineered structures. Tissues, such as skin, act as biological metamaterials whose internal structures, such as packed collagen fibers, produce nonlinear and directional responses. Similarly, hierarchical thread packing governs the mechanical response of textiles. However, the capability of encoding textiles at the fabric level and at a sufficient resolution remains limited. Embroidering triangularly tiled zigzag patterns of inextensible thread on a stretchable fabric is demonstrated to encode distributed, directional stress-strain behavior at subcentimeter resolution, sufficient to mimic complex physiological characteristics such as Langer lines of the skin. The triangular unit cells solved the Königsberg bridge problem of filling a plane with a continuous thread pair. The encoding maps directionality, directional contrast, and magnitude, three parameters that define unit cells' compliance, into hue-saturation-value color space for rapid qualitative design. Cross-talk-free arrays of embroidered restrictors enable scalable augmentation of textile mechanics. The transition threshold from the matrix- to fiber-defined behavior is achieved with 85% fidelity, enabling customizable shape-morphing structures such as restrictor bladder actuators and feet-conforming shoes. Industry-standard machine embroidery scales biomechanics-inspired structures for wearable and environmental robotics and promises future biohybrid technologies.
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http://dx.doi.org/10.1002/adma.202500959 | DOI Listing |
Pancreatic ductal adenocarcinoma (PDAc) is a deadly malignancy, most commonly diagnosed in advanced stages when no curative treatments are available. The development of new models that aid ongoing investigation into the mechanisms by which it initiates, disseminates, and evades treatment is of the utmost importance. models that accurately recapitulate the features and spectrum of human pancreatic cancer are paramount to make a dent in this disease as two decades of the standard-of-care have failed to substantially improve survival.
View Article and Find Full Text PDFFront Cell Dev Biol
July 2025
IRIBHM, Jacques E. Dumont, Faculty of Medicine, Université Libre de Bruxelles ULB, Brussels, Belgium.
Colorectal cancer (CRC) remains the second leading cause of cancer-related deaths worldwide, with its incidence continuing to rise. Regorafenib, a multi-kinase inhibitor approved for palliative treatment, has been shown to extend survival in patients with metastatic CRC (mCRC) who have failed standard therapies. However, its clinical benefit is limited to a subset of patients, is typically short-lived, and is often accompanied by significant toxicity.
View Article and Find Full Text PDFAm J Perinatol
August 2025
Neonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, California.
Umbilical line insertion involves discomfort for preterm infants. We hypothesized that a 10- to 20-cm umbilical cord segment can be catheterized with an appropriate guide wire. This may facilitate line establishment with minimal baby discomfort.
View Article and Find Full Text PDFLancet Oncol
August 2025
Division of Cancer Sciences, University of Manchester, Manchester, UK; The Christie Hospital NHS Foundation Trust, Manchester, UK; Department of Urology, Salford Royal Hospital, Manchester, UK.
Adv Mater
July 2025
IMS Lab, Institute of Technology, University of Tartu, Nooruse 1, Tartu, 50411, Estonia.
Morphological anisotropies and nonlinear mechanical properties shape the kinematic agility of organisms and engineered structures. Tissues, such as skin, act as biological metamaterials whose internal structures, such as packed collagen fibers, produce nonlinear and directional responses. Similarly, hierarchical thread packing governs the mechanical response of textiles.
View Article and Find Full Text PDF