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Viral suppression rates among children and young adolescents living with HIV (CYALHIV) has been reported to be lower compared to adults. Follow up through viral load monitoring may influence their health outcomes. In this cross-sectional study we determined viral load monitoring practices and correlates of viral non-suppression of all CYALHIV in the main public hospitals in Kiambu County, Kenya. Data was abstracted from electronic medical records. Multivariable log binomial regression was used to estimate prevalence ratios (PR) and assess correlates of viral non-suppression. Adherence to viral load testing guidelines was also assessed. Viral non-suppression was defined as a viral load (VL) >1000c/ml. Of the 252 CYALHIV, the median age was 11 (IQR: 7-13) years. At the most current VL, 14% were non-suppressed. Correlates of non-suppression included a history of Tuberculosis, [aPR = 4.25; 95% CI = 1.41-12.8; = .01], antiretroviral drug side effects [aPR = 3.01; 95% CI = 1.37-6.62; = 0.006] and having received enhanced adherence counselling (EAC) [aPR = 5.32; 95% CI = 2.00-14.15; = .001]. Although the timing of baseline VL tests improved over the years, routine VL monitoring as per the guidelines remained suboptimal. There is need for adherence to VL monitoring guidelines for prompt action among non-suppressed children.
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http://dx.doi.org/10.1177/30502225251311664 | DOI Listing |
PLoS One
September 2025
School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.
Background: Despite advances in HIV care, viral load suppression (VLS) among adolescents living with HIV (ALHIV) in Uganda continue to lag behind that of adults, even with the introduction of dolutegravir (DTG)-based regimens, the Youth and Adolescent Peer Supporter (YAPS) model, and community-based approaches. Understanding factors associated with HIV viral load non-suppression in this population is critical to inform HIV treatment policy. This study assessed the prevalence and predictors of viral load non-suppression among ALHIV aged 10-19 years on DTG-based ART in Soroti City, Uganda.
View Article and Find Full Text PDFBackground: Cytomegalovirus (CMV) viremia is a critical concern and known by the presence of the virus DNA in the blood, which poses sever risks and develops many complications in immuno-compromised patients. When CMV is untreated, it can cause pneumonitis, colitis, hepatitis, and encephalitis. Current diagnosis relies on molecular methods with qPCR as the preferred method.
View Article and Find Full Text PDFJ Viral Hepat
October 2025
Department of Obstetrics and Gynecology, the Second Hospital of Nanjing, and Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.
Hepatitis B virus (HBV) infection is a serious public health concern worldwide, especially during pregnancy due to the associated health risks for the mother and fetus. This study aimed to explore the relationship between alanine aminotransferase (ALT) levels, age and HBV DNA levels in pregnant women with chronic HBV infection. Our cohort study included 1743 pregnant women with HBV who gave birth from January 2021 to June 2024.
View Article and Find Full Text PDFPLOS Glob Public Health
September 2025
Department of Biology, University of Ottawa, Ottawa, Ontario, Canada.
Built environment surveillance has shown promise for monitoring COVID-19 burden at granular geographic scales, but its utility for surveillance across larger areas and populations is unknown. Our study aims to evaluate the role of built environment detection of SARS-CoV-2 for the surveillance of COVID-19 across broad geographies and populations. We conducted a prospective city-wide sampling study to examine the relationship between SARS-CoV-2 on floors and COVID-19 burden.
View Article and Find Full Text PDFJ Infect Dev Ctries
August 2025
Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Cameroon.
Introduction: Despite increased national and international funding to combat the human immunodeficiency virus (HIV) pandemic, prison health services remain underfunded, resulting in poor HIV management among inmates. This study assessed viral suppression rates among HIV-positive inmates across four central prisons in Cameroon to evaluate the effectiveness of antiretroviral therapy (ART) in these settings.
Methodology: This cross-sectional study included four central prisons-prisons A, B, C, and D-each located in different regions of Cameroon.