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Rationale & Objective: A population health management intervention for a pragmatic cluster randomized control trial (Kidney CHAMP) aimed to improve care and outcomes in patients with chronic kidney disease (CKD) at high-risk of progression to dialysis dependence but not seeing a nephrologist. The Kidney CHAMP intervention provided comanagement support to primary care providers by nephrology electronic-consult, pharmacist-directed medication reconciliation, and nurse-delivered CKD patient education. We sought to learn patient perceptions of Kidney CHAMP intervention and whether the intervention improved their understanding of CKD.
Study Design: An ancillary study of Kidney CHAMP using qualitative methods.
Setting & Participants: Participants were sampled from Kidney CHAMP intervention group using 3 predefined strata (racial/ethnic minorities, low socioeconomic status, and multimorbidities) from May 2021 to February 2022.
Analytical Approach: We conducted semistructured televideo or telephone interviews that were transcribed and then inductively coded by 2 data analysts until thematic saturation was reached. Conventional content and thematic analyses were performed.
Results: In 45 patient interviews (mean age 75 ± 8 years, 44% women, 9% non-White race, and 59% low socioeconomic status), we identified 4 themes. First, patients expressed support for CKD comanagement by the primary care providers (PCPs) and nephrology team. Second, education sessions had variable effect on improving patients'understanding of CKD and its health implications. Third, patients' self-efficacy and understanding of CKD management varied and was influenced by their understanding of its health implications. Fourth, patients appreciated education sessions and wanted more frequent sessions and actionable individualized guidance.
Limitations: Low representation of non-White individuals, recall bias, and lack of validated measures for health literacy, patient knowledge, and activation.
Conclusions: Patients with CKD who are managed by their PCP were supportive of remote comanagement by a nephrologist. Patients perceive some aspects of CKD health education to be beneficial; however, more effective approaches to communicating risk of CKD development and progression are needed.
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http://dx.doi.org/10.1016/j.xkme.2025.101025 | DOI Listing |
Kidney Med
July 2025
Renal-Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA.
Rationale & Objective: A population health management intervention for a pragmatic cluster randomized control trial (Kidney CHAMP) aimed to improve care and outcomes in patients with chronic kidney disease (CKD) at high-risk of progression to dialysis dependence but not seeing a nephrologist. The Kidney CHAMP intervention provided comanagement support to primary care providers by nephrology electronic-consult, pharmacist-directed medication reconciliation, and nurse-delivered CKD patient education. We sought to learn patient perceptions of Kidney CHAMP intervention and whether the intervention improved their understanding of CKD.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
July 2025
Research Group Translational Radiotheranostics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany.
Purpose: Despite the clinical evidence of actinium-225 (Ac)-based targeted alpha therapies (TαT) efficacy, optimized treatment regimens are needed to improve overall clinical response rates and decrease toxicities. The nuclear recoil effect of Ac and its resulting daughter nuclides have been hypothesized to contribute to non-targeted damage. However, a lack of generator concepts for radionuclidically pure francium-221 (Fr), involvement of strong acids for elution, and its short half-life (4.
View Article and Find Full Text PDFAm J Nephrol
June 2025
Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Introduction: Patients with chronic kidney disease (CKD) are at risk of medication therapy problems (MTPs) due to high comorbidity and medication burden. Using data from the Kidney Coordinated HeAlth Management Partnership (Kidney CHAMP) trial, we used machine learning to build a predictive model to identify MTP high-risk patients with CKD in the primary care setting.
Methods: We used baseline data from patients enrolled in the intervention arm of the Kidney CHAMP trial, completed May 2019-July 2022, which tested a population health management strategy, including medication management, for improving CKD care.
Kidney Med
May 2025
Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Rationale & Objective: Medication therapy problems (MTPs) are therapeutic issues related to medications that may cause undesirable events. People with chronic kidney disease (CKD) are at high risk of experiencing MTPs owing to comorbid conditions and medication burden. This study characterizes MTPs in individuals enrolled in the Kidney Coordinated Health Management Partnership trial and evaluates the intervention's effect on MTPs.
View Article and Find Full Text PDFJ Am Soc Nephrol
May 2025
Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Key Points: Implementation gaps in guideline-concordant care for CKD are associated with poor clinical outcomes. A population health management–based, multidisciplinary approach improved exposure days to sodium-glucose cotransporter-2 inhibitor and glucagon-like peptide-1 receptor agonists compared with usual care. Angiotensin-converting enzyme inhibitor/angiotensin receptor blocker in albuminuric patients and statin use was not improved, nor was BP control, glycemic control, or albuminuria testing.
View Article and Find Full Text PDF