Dimorpoloids A-D, Three Rearranged Diterpenoids and One Unique Daphnane-Type Diterpenoid from .

The first phytochemical investigation of led to the isolation and characterization of four novel diterpenoids, namely, dimorpoloids A-D (-), along with two biosynthetically related known diterpenoids. Compounds and are rearranged -cleistanthane diterpenoids with a 6/7/6-fused tricyclic scaffold. Compound is a rearranged 17---labdane-type diterpenoid, distinguished by a novel tropone ring system in its molecular architecture. Compound represents the first daphnane-type diterpenoid featuring an aromatic C-ring system. Their structures were elucidated by spectroscopic analysis and quantum chemical calculations. Putative biosynthetic pathways for compounds - are proposed. Compounds and - exhibited antiadipogenic effects in 3T3-L1 adipocytes, and the most potent compound showed an EC value of 3.29 ± 0.53 μM.