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Background: Research has shown that parental behavior significantly influences children’s pain experiences. The Inventory of Parent/Caregiver Responses to Children’s Pain Experience (IRPEDNA) is a validated tool used to measure these reactions. Studies using the IRPEDNA have found that parental responses, shaped by cultural influences and individual perceptions, are closely linked to children’s pain coping strategies and overall distress levels. The aim of this study was to translate, culturally adapt and validate the IRPEDNA for use in the Croatian language (IRPEDNA-Cro).
Methods: We conducted a cross-sectional study between October and December 2012. A forward-backwards translation of the IRPEDNA from English to the Croatian language was performed according to the cross-cultural adaptation guidelines of self-report measures. The study participants were 200 parents: 100 mothers and 100 fathers from 100 families (both mother and father from the same family were included). They received IRPEDNA-Cro and Positive and Negative Affect Schedule (PANAS) questionnaires.
Results: The three subscales of IRPEDNA-Cro showed good reliability: Solicitousness (α = 0.81, 95% CI 0.76 to 0.85), Discouragement (α = 0.75, 95% CI 0.68 to 0.80) and Promotion of Well Being (α = 0.75, 95% CI 0.68 to 0.80). The overall scale showed high reliability in terms of both internal consistency (α = 0.83, 95% CI 0.79 to 0.87) and in association with positive PANAS was α = 0.78 (95% CI 0.72 to 0.83), while reliability for negative PANAS scale was α = 0.87 (95% CI 0.84 to 0.90). Regression analysis showed that the Discouragement scale on IRPEDNA was the best predictor of both positive and negative affect.
Conclusion: This article presents the translation and preliminary validation of a self-administered instrument designed to measure parents/caregivers’ responses to children’s pain behaviors in the Croatian language (IRPEDNA-Cro). The data showed that IRPEDNA-Cro provides valid and reliable information when used with Croatian-speaking adults.
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http://dx.doi.org/10.1186/s40359-025-02976-7 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute and Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
MS4A4A belongs to the MS4A tetraspan protein superfamily and is selectively expressed by the monocyte-macrophage lineage. In this study, we aimed to evaluate the role of MS4A4A+ macrophages in rheumatoid arthritis (RA) pathogenesis and response to treatment. RNA sequencing and immunohistochemistry of synovial samples from either early treatment-naïve or active chronic RA patients showed that MS4A4A expression positively correlated with synovial inflammation.
View Article and Find Full Text PDFPhysiother Theory Pract
September 2025
School of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
Background: Knee osteoarthritis (OA) causes pain and diminishes quality of life. Backward walking exercise (BWE) has been shown to improve lower muscle strength and reduce knee adduction moment, making it a recommended intervention for knee OA rehabilitation. This study aims to evaluate the effectiveness of BWE combined with conventional rehabilitation programs on pain intensity and disability among individuals with knee OA.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Division of Cardiology, Duke University Hospital, Durham, North Carolina.
Importance: Previous data suggest that the time changes associated with daylight savings time (DST) may be associated with an increased incidence of acute myocardial infarction (AMI).
Objective: To determine whether the incidence of patients presenting with AMI is greater during the weeks during or after DST and compare the in-hospital clinical events between the week before DST and after DST.
Design, Setting, And Participants: This cross-sectional study examined patients enrolled in the Chest Pain MI Registry from 2013 to 2022.
Acta Neurol Belg
September 2025
Neuroscience Research Australia, University of New South Wales, Sydney, Australia.
Objectives: Patients diagnosed with amyotrophic lateral sclerosis (ALS) typically describe symptoms of fatigue. Despite this frequency, the underlying mechanisms of fatigue are poorly understood, and are likely multifactorial. To help clarify mechanisms, the present systematic review was undertaken to determine the risk factors related to fatigue in ALS.
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