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As the importance of the prevention and premanagement of cardiovascular and cerebrovascular diseases continues to emerge, research is being conducted globally to create and compare risk factor prediction models using health examination big data. In this study, health insurance data were used to predict the incidence of cardiocerebrovascular disease using various models and compare the performance of the models on samples with different initial risk levels. This study analyzed data from 410,859 individuals from the National Health Insurance Service between 2002 and 2019. This study deployed various linear models to predict the occurrence of cardiocerebrovascular diseases in two distinct samples. Models based on logistic regression analysis with penalty terms on the objective function were used, and their predictive performances were compared using multiple evaluation metrics, including the area under the receiver operating characteristic curve. The logistic regression model incorporating variables selected by the LASSO algorithm exhibited superior predictive performance relative to other models, although the differences were not statistically significant. The models demonstrated improved performance for samples with higher incidence rates and initial risk levels. This study predicted and compared the incidence of cardiocerebrovascular disease (CCVD) in patients with different health conditions using national sample cohort data from the National Health Insurance Service. The findings underscore the importance of developing diverse models to predict diseases like CCVD, which have high medical costs and incidence rates, thus informing the development of healthcare policies.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12216109 | PMC |
http://dx.doi.org/10.1038/s41598-025-94888-0 | DOI Listing |
JAMA Netw Open
September 2025
Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Importance: Patients with advanced cancer frequently receive broad-spectrum antibiotics, but changing use patterns across the end-of-life trajectory remain poorly understood.
Objective: To describe the patterns of broad-spectrum antibiotic use across defined end-of-life intervals in patients with advanced cancer.
Design, Setting, And Participants: This nationwide, population-based, retrospective cohort study used data from the South Korean National Health Insurance Service database to examine broad-spectrum antibiotic use among patients with advanced cancer who died between July 1, 2002, and December 31, 2021.
Diabetes Ther
September 2025
Eli Lilly and Company, Lilly Corporate Center, 893 Delaware Street, Indianapolis, IN, 46225, USA.
Introduction: This study examines the characteristics of adults with type 2 diabetes (T2D) who were not initially treated with an antihyperglycemic agent (AHA).
Methods: The analyses used Optum de-identified Market Clarity data from January 2013 through September 2023. The US study included nonpregnant adults with T2D who were continuously insured from 1 year prior through 5 years post diagnosis and did not fill a prescription for an AHA in the year after their initial T2D diagnosis.
Cancer Causes Control
September 2025
Department of Nursing Research, The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, 460 W 10th Ave, Columbus, OH, 43210, USA.
Purpose: Understanding how place of residence affects cancer-related health risks is paramount to addressing health disparities in sexual and gender minority (SGM) cancer survivors. This study examined the associations between urbanicity and other social drivers of health on current tobacco and alcohol use in SGM cancer survivors.
Methods: The OUT: National Cancer Survey Study was a cross-sectional, online survey created by the National LGBT Cancer Network (NLCN) from September 2020 to March 2021, targeting U.
Int J Clin Oncol
September 2025
Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Background: Limited data are available on relative survival (RS) among cancer survivors enrolled in private cancer insurance in Japan. Additionally, the incidence of second primary cancers or recurrences, as applicable, after a certain period remains unclear.
Methods: We analyzed 8,846 cancer survivors, including carcinoma in situ, aged 15-79 years, enrolled in private cancer insurance between April 2005 and September 2021, and diagnosed before April 2022.
Int Arch Occup Environ Health
September 2025
Department of Mechanical Engineering, Politecnico di Milano, Milan, Italy.
Purpose: To investigate the role of personal risk factors in the occurrence of the vascular, neurological and fibroproliferative disorders of the hand-arm vibration syndrome (HAVS) in workers groups exposed to hand-transmitted vibration (HTV).
Methods: HAVS prevalence and incidence data were pooled across a series of cross-sectional studies (total sample: 1272 HTV workers, 579 controls) and prospective cohort studies (total sample: 377 HTV workers, 138 controls) conducted in Central and North-Eastern Italy. The pooled studies included detailed individual-level information about HTV exposure, personal risk factors, medical comorbidities and HAVS disorders.