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Accurate classification of biomedical signals is crucial for advancing non-invasive diagnostic methods, particularly for identifying gastrointestinal and related medical conditions where conventional techniques often fall short. An ensemble learning framework was developed by integrating Random Forest, Support Vector Machines (SVM), and Convolutional Neural Networks (CNN) to classify spectrogram images generated from percussion and palpation signals. The framework employs Short-Time Fourier Transform (STFT) to extract spectral and temporal information, enabling accurate signal processing and classification into distinct anatomical regions. The ensemble model combines the strengths of its components: Random Forest mitigates overfitting, SVM handles high-dimensional data, and CNN extracts spatial features within a robust preprocessing pipeline to ensure data consistency. By achieving a classification accuracy of 95.4%, the ensemble framework outperformed traditional classifiers in capturing subtle diagnostic variations. This method offers a robust solution for biomedical signal classification and has potential applications in clinical diagnostics. Future research directions include real-time clinical integration and multi-modal data incorporation to further enhance its applicability.
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http://dx.doi.org/10.1038/s41598-025-05027-8 | DOI Listing |
J Neurosci
September 2025
Center for Studies in Behavioural Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada, H4B 1R6
Adaptive behavior depends on a dynamic balance between acquisition and extinction memories. Male and female rodents differ in extinction learning rates, suggestion potential sex-based differences in this balance. In males, deletion of extinction-recruited neurons in the central nucleus (CN) of the amygdala impairs extinction retrieval, shifting behavior toward acquisition (Lay et al.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Computational Biology, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), Okhla Phase III, New Delhi, 110020, India; Infosys Centre for Artificial Intelligence, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), Okhla Phase III, New Delhi, 110020, In
Understanding the structural and functional diversity of toxin proteins is critical for elucidating macromolecular behavior, mechanistic variability, and structure-driven bioactivity. Traditional approaches have primarily focused on binary toxicity prediction, offering limited resolution into distinct modes of action of toxins. Here, we present MultiTox, an ensemble stacking framework for the classification of toxin proteins based on their molecular mode of action: neurotoxins, cytotoxins, hemotoxins, and enterotoxins.
View Article and Find Full Text PDFEcotoxicol Environ Saf
September 2025
Department of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address:
Background: Prostate cancer (PRAD) is a common malignancy in men, and exposure to soil pollutants may contribute to its development. And exposure to soil pollutant has been linked to its development, as well as to other diseases including cardiovascular disorders, neurological conditions, and additional cancers.
Methods: This study integrates network toxicology, machine learning, and advanced technologies to investigate the mechanisms through which soil pollutants affect prostate cancer.
PLoS One
September 2025
Institute of Computational Science and Technology, Guangzhou University, Guangzhou, China.
MicroRNAs (miRNAs) are critical regulators of gene expression in cancer biology, yet their spatial dynamics within tumor microenvironments (TMEs) remain underexplored due to technical limitations in current spatial transcriptomics (ST) technologies. To address this gap, we present STmiR, a novel XGBoost-based framework for spatially resolved miRNA activity prediction. STmiR integrates bulk RNA-seq data (TCGA and CCLE) with spatial transcriptomics profiles to model nonlinear miRNA-mRNA interactions, achieving high predictive accuracy (Spearman's ρ > 0.
View Article and Find Full Text PDFPLoS One
September 2025
Center for Radiological Research, Columbia University Irving Medical Center, New York, New York, United States of America.
In the event of a large-scale radiological or nuclear emergency, a rapid, high-throughput screening tool will be essential for efficient triage of potentially exposed individuals, optimizing scarce medical resources and ensuring timely care. The objective of this work was to characterize the effects of age and sex on two intracellular lymphocyte protein biomarkers, BAX and p53, for early radiation exposure classification in the human population, using an imaging flow cytometry-based platform for rapid biomarker quantification in whole blood samples. Peripheral blood samples from male and female donors, across three adult age groups (young adult, middle-aged, senior) and a juvenile cohort, were X-irradiated (0-5 Gy), and biomarker expression was quantified at two- and three-days post-exposure.
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