EchoBack-CAR T cells: Tuning immunity with sound.

Clin Transl Med

Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA.

Published: July 2025


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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211968PMC
http://dx.doi.org/10.1002/ctm2.70391DOI Listing

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EchoBack-CAR T cells: Tuning immunity with sound.

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Article Synopsis
  • Chimeric antigen receptor (CAR) T cell therapy faces challenges in solid tumors, including toxicity and T cell exhaustion.
  • The engineered EchoBack-CAR T cells, activated by focused-ultrasound, show improved persistence and effectiveness against glioblastoma, achieving significant tumor suppression without harming healthy tissue.
  • This approach has been adapted for prostate cancer treatment, highlighting its potential as a safe and efficient method for battling solid tumors.
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