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Polymorphic ventricular tachycardia (PMVT) is a potentially life-threatening arrhythmia, typically associated with acute myocardial ischemia or inherited channelopathies. We present a case of PMVT in the context of critical coronary artery disease (CAD) but without biomarker-evident myocardial injury, such as troponin elevation. We present a case of a 61-year-old man with critical left anterior descending (LAD) artery stenosis who developed symptomatic PMVT. This case highlights the paradox of negative troponin values despite severe coronary pathology and a life-threatening arrhythmia. Despite initial normal troponin levels, the patient's recurrent chest pain and arrhythmias were ultimately attributed to critical LAD stenosis, which was successfully treated with percutaneous coronary intervention (PCI). This case emphasizes the importance of considering high-risk coronary disease, particularly in patients with exertional symptoms and arrhythmias, even when initial biomarkers may be reassuring. It underscores the importance of considering ischemia even when troponin levels are normal, particularly in patients with unstable angina. The case illustrates the limitations of relying solely on troponin for risk stratification in acute coronary presentations and supports the need for comprehensive clinical and electrocardiographic evaluation.
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http://dx.doi.org/10.7759/cureus.85016 | DOI Listing |
J Electrocardiol
August 2025
Cardiology, Government TD Medical College Alappuzha, Kerala, India.
We report an elderly woman who presented with cardiac arrest due to complete heart block. She developed progressive T-wave inversions in leads V3-V6 due to pacinginduced cardiac memory, accompanied by marked QTc prolongation. These repolarization abnormalities occurred despite normal electrolytes and non-obstructive coronary angiography and culminated in polymorphic ventricular tachycardia.
View Article and Find Full Text PDFJACC Clin Electrophysiol
September 2025
Istituto Auxologico Italiano IRCCS, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milano, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy. Electronic address:
Calmodulinopathies are very rare genetic disorders associated with a high risk for sudden cardiac death. Disease-causing variants in 1 of the 3 identical CALM genes cause severe forms of long QT syndrome, catecholaminergic polymorphic ventricular tachycardia, or idiopathic ventricular fibrillation, and there are many unanswered questions concerning management and underlying mechanisms. What is currently known depends largely on the initial publications from the ICamR (International Calmodulinopathy Registry).
View Article and Find Full Text PDFPediatr Cardiol
August 2025
Department of Pediatric Cardiology, Cleveland Clinic Children's, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Adult studies establish an association between mitral valve pathology, namely mitral annular disjunction (MAD) and mitral valve prolapse (MVP), and ventricular arrhythmias. Data in the pediatric Marfan population is limited. To assess the association between (1) MAD and ventricular ectopy (VE), non-sustained ventricular tachycardia (NSVT) and ventricular tachycardia (VT); (2) MVP and VE, NSVT and VT and (3) MAD and MVP in the pediatric Marfan population.
View Article and Find Full Text PDFJACC Case Rep
August 2025
Department of Neuroscience, Imaging and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy; University Cardiology Division, SS Annunziata Polyclinic University Hospital, Chieti, Italy; Department of Clinical Sciences, Lund University, Malmö, Sweden. Electronic address: fab
Background: Imagenomics is an emerging clinical framework that combines advanced imaging and genetic profiling to refine risk stratification and advance precision medicine in the management of ventricular arrhythmias.
Case Summary: A 43-year-old woman presented with palpitations and presyncope. Ambulatory electrocardiogram revealed frequent premature ventricular contractions and nonsustained ventricular tachycardia, consistently initiated by a premature ventricular contraction with distinct morphology.
Commun Med (Lond)
August 2025
Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Background: The fovea is one of the most crucial parts of the visual system and has a special structure. We aimed to identify susceptibility single nucleotide polymorphisms (SNPs) for foveal thickness in a large Japanese cohort.
Methods: Genome-wide association study (GWAS) and replication studies were conducted in 9850 individuals from the Nagahama Study (from 2013 to 2016) and 935 individuals from the Hisayama Study.