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Black adults experience the highest incidence and/or mortality rates for many commonly diagnosed cancers; yet they are underrepresented in cancer basic, applied, and translational research. This underrepresentation is greatest among Black adults living in low-income communities. There are many barriers to these individuals participating in cancer research, including limited effective research engagement strategies. This paper describes the University of Florida (UF) Health Cancer Center Community-Partnered Cancer Disparities Research Collaborative (CDRC) model and its implementation. The UF CDRC model consists of human and physical infrastructure for the sustained engagement of Black adults within low-income communities in cancer research. The CDRC model is culturally sensitive and informed by the community-based participatory research approach, which requires equitable partnerships between scientific researchers and community members. The human infrastructure of the CDRC model includes faculty and community researchers, pastors, and culturally diverse university students. The physical infrastructure of the CDRC model consists of 10 predominantly Black churches and a community-based multipurpose building, all of which are community outreach and research sites. Examples of evidence supporting the use of the CDRC model includes (a) the successful recruitment, training, and retention of trusted community members and leaders as major research partners in the CDRC, and (b) the pipeline development of culturally sensitive student and faculty health equity researchers. The CDRC model is a novel, replicable infrastructure model for the sustained engagement of Black adults within low-income communities in cancer prevention, treatment, and survivorship research. It is dedicated to reducing cancer disparities that plague Black communities.
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http://dx.doi.org/10.1007/s10900-025-01494-2 | DOI Listing |
Sci Rep
July 2025
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
The diverse and heterogeneous nature of cancer is a fundamental characteristic that is responsible for therapy resistance, progression, and recurrence of disease. In order to enhance therapeutic efficacy, novel combination therapies are currently being proposed and utilized in clinical practice to effectively manage or retard disease progression. Several factors contribute to therapeutic resistance, including elevated expression of survival factors, mutations in genes that limit therapeutic effectiveness, multidrug resistance, and the potential involvement of cancer stem cells.
View Article and Find Full Text PDFJ Community Health
June 2025
University of Florida, Gainesville, FL, USA.
Black adults experience the highest incidence and/or mortality rates for many commonly diagnosed cancers; yet they are underrepresented in cancer basic, applied, and translational research. This underrepresentation is greatest among Black adults living in low-income communities. There are many barriers to these individuals participating in cancer research, including limited effective research engagement strategies.
View Article and Find Full Text PDFPediatr Cardiol
February 2025
Division of Cardiology, Department of Pediatrics, Oregon Health & Science University, 707 SW Gaines Street, Mailcode: CDRC-P, Portland, OR, 97239, USA.
Arrhythmias are common after the Fontan operation and increase risk of morbidity and mortality. Their impact on late outcomes remains poorly understood. Our objective was to assess whether long-term studies after the Fontan incorporated the impact of arrhythmia characteristics on outcome.
View Article and Find Full Text PDFPediatr Cardiol
October 2024
Department of Pediatrics, Oregon Health & Science University, 707 SW Gaines St., Mailcode: CDRC-P, Portland, OR, 97239, USA.
Nutr J
July 2024
Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: No study has investigated the relationship between dietary total antioxidant capacity and sarcopenia so far.
Objective: This study aimed to investigate the association between dietary Total Antioxidant Capacity (d-TAC) and sarcopenia in elderly adults.
Methods: In this cross-sectional study we enrolled 300 elderly people (150 men and 150 women) aged ≥ 55 years using cluster random sampling method.