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Objective: The health care industry accounts for 8.5% of US greenhouse gas emissions, with helicopter air ambulances (HAAs) contributing significantly. This study investigates the extent to which interfacility helicopter transfer interval affects patient outcomes, an essential consideration when optimizing flight paths.
Methods: We retrospectively analyzed adult HAA data from a large mid-Atlantic transport provider. Transport interval was defined as the time from dispatch to arrival at the receiving hospital. Patient diagnoses were categorized as cardiac, medical, neurological, surgical, and trauma. Discharge dispositions were grouped as home, hospice/morgue, and facility. Logistic regression analyzed discharge disposition as the dependent variable with transport interval and diagnostic category as independent variables.
Results: Analysis of 2,626 interfacility transfers revealed a significant logistic regression model (χ² = 202.67, df = 10, P < .001), explaining 4% to 8% of discharge variability. Although transport interval was a predictor (χ² = 45.32, df = 2, P < .001), the odds ratios (0.995 and 0.991) indicated negligible impact on outcomes.
Conclusion: The weak association between transport interval and discharge outcomes suggests that small variations in interfacility transport interval could be allowed for when optimizing helicopter flight routes for efficiency. Optimization could reduce fuel consumption without negatively affecting patient outcomes.
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http://dx.doi.org/10.1016/j.amj.2025.03.005 | DOI Listing |
Ren Fail
December 2025
Department of Nephrology, National Clinical Key Specialty Construction Program (2023); Institute of Nephrology; Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affil
Sodium-glucose cotransporter 2 inhibitors reduced proteinuria in patients with IgA nephropathy; however, their efficacy in patients at high risk of progression receiving immunosuppressive agents and renin angiotensin-aldosterone system inhibitors remains unclear. After 3 months of low-dose steroid alone or combined with mycophenolate mofetil, as well as renin angiotensin-aldosterone system inhibitors treatment, 105 biopsy-proven IgA nephropathy patients with proteinuria greater than 0.5 g/d were included in this study.
View Article and Find Full Text PDFIntroduction Systemic inflammation alters lipid metabolism by suppressing hepatic lipoprotein synthesis, increasing catabolism, and impairing reverse cholesterol transport. These changes result in reduced levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC), despite elevated cardiovascular risk, which is a phenomenon termed the "inflammatory lipid paradox." While well-characterized in chronic inflammatory diseases, such as rheumatoid arthritis, its prevalence and clinical impact in hospitalized adults with systemic inflammation remain underexplored.
View Article and Find Full Text PDFEnviron Int
September 2025
Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA. Electronic address:
Longer, more severe wildfire seasons are becoming the norm in fire-prone areas. Prescribed burning is a tool used to mitigate wildfire spread. However, prescribed burning also contributes to air pollution, including PM (particulate matter with aerodynamic diameter <= 2.
View Article and Find Full Text PDFNeurotoxicology
September 2025
Department of Neurology, Barrow Neurological Institute, 240 W Thomas Rd, Phoenix, AZ 85013 USA; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110 USA; Program in Physical Therapy, Washington University School of Medicine, 660 S. Euclid Ave, St.
Background And Objective: Excessive exposure to manganese (Mn) produces a clinical syndrome of parkinsonism and cognitive impairment. However, our understanding of the mechanisms of Mn neurotoxicity remains limited. This study aimed to evaluate the relationships between Mn exposure, cholinergic function, and cognitive impairment in exposed workers.
View Article and Find Full Text PDFClin Nutr ESPEN
September 2025
Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address:
Background & Aims: It remains unclear whether sodium-glucose co-transporter-2 (SGLT2) inhibitors are effective for patients with underweight. This study aimed to elucidate the association between SGLT2 inhibitors use and prognosis in underweight patients with diabetes mellitus (DM) and HF.
Methods: This study was a post-hoc analysis of data from the Japanese Registry of Acute Decompensated Heart Failure, a prospective, multicenter, observational, nationwide registry.