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What the intensivist should know about hyperammonemia without liver failure.
J Crit Care
October 2025
Resident in ICU, CHU UCL Godinne Namur, UCL Louvain Medical School, Belgium. Electronic address:
What every Intensivist should know about ... Ammonia in liver failure.
J Crit Care
June 2024
Transplant Unit, Intensive Care Unit, Curry Cabral Hospital, Nova Medical School, Lisbon, Portugal. Electronic address:
Purpose: Acute liver failure (ALF) or acute-on-chronic liver failure (ACLF) patients have high short-term mortality and morbidity. In the context of liver failure, increased serum ammonia is associated with worse neurological outcomes, including high-grade hepatic encephalopathy (HE), cerebral edema, and intracranial hypertension. Besides its neurotoxicity, hyperammonemia may contribute to immune dysfunction and the risk of infection, a frequent trigger for multi-organ failure in these patients.
View Article and Find Full Text PDFManagement of late onset urea cycle disorders-a remaining challenge for the intensivist?
Ann Intensive Care
January 2021
Department of Intensive Care, Université Libre de Bruxelles (ULB), CHU Brugmann-Brugmann University Hospital, 4, Place Arthur Van Gehuchten, 1020, Brussels, Belgium.
Background: Hyperammonemia caused by a disorder of the urea cycle is a rare cause of metabolic encephalopathy that may be underdiagnosed by the adult intensivists because of its rarity. Urea cycle disorders are autosomal recessive diseases except for ornithine transcarbamylase deficiency (OTCD) that is X-linked. Optimal treatment is crucial to improve prognosis.
View Article and Find Full Text PDFUreaplasma parvum causes hyperammonemia presenting as refractory status epilepticus after kidney transplant.
J Crit Care
June 2020
Fondation Ophtalmologique Adolphe de Rothschild, Department of Neurointensive Care, Paris, France. Electronic address:
Purpose: Alert intensivists about the diagnostic pitfalls arising from hyperammonemia due to Ureaplasma infections in post-transplant patients.
Materials And Methods: Clinical observation of one patient.
Case Report: A 65-year-old female with a medical history of semi-recent kidney transplant was admitted to the Intensive Care Unit for refractory status epilepticus.