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http://dx.doi.org/10.1007/s15010-025-02592-y | DOI Listing |
Ocul Immunol Inflamm
September 2025
National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
Purpose: To report pyramidal-like, hyperreflective changes of the outer retina and retinal pigmented epithelium (RPE) in three patients with an atypical non-syphilitic outer retinopathy.
Study Design/materials And Methods: Single institutional case series conducted at the National Eye Institute, National Institutes of Health.
Results: Hyperreflective, pyramidal lesions of the outer retina and RPE have been described in patients with syphilitic posterior segment uveitis.
Ophthalmology
August 2025
Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California; Department of Ophthalmology, Los Angeles General Medical Center, Los Angeles, California. Electronic address:
Dermatol Reports
July 2025
Department of Dermatology, University of Rochester Medical Center, Rochester (NY).
Syphilitic alopecia (SA) and ocular syphilis (OS) are rare manifestations of syphilis, typically reported together in immunocompromised patients. We present a unique case of mixed-pattern, essential, SA of the scalp and OS in the form of anterior uveitis in an otherwise immunocompetent, HIV-negative, 46-year-old female. Briefly, the patient initially presented with sudden-onset scalp hair loss that was initially diagnosed as atypical alopecia areata but failed to respond to typical alopecia areata-directed therapy.
View Article and Find Full Text PDFBMJ Case Rep
July 2025
Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland.
We describe the challenging clinical scenario of an adult male presenting with acute, uniocular, sight-threatening panuveitis to a tertiary eye emergency department. Clinically, this was characterised by painless anterior chamber inflammation and significant vitritis, precluding clear fundal view.We outline the initial approach to establishing an appropriate working diagnosis, the laboratory investigations, multimodal imaging undertaken and empirical treatment administered in the first instance for imminently sight-threatening infectious causes.
View Article and Find Full Text PDFInfection
June 2025
Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku City, 783-8505, Kochi, Japan.