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The cerebral arterial circle displays significant variation, with infrequent configurations often ascertained through contemporary imaging techniques. We present a sporadic case of a duplicated superior cerebellar artery (SCA) discovered during magnetic resonance angiography (MRA) of a 58-year-old female patient. Typical SCA emanates from the distal basilar artery (BA), whereas a duplicate one originates from the pre-cavernous segment of the internal carotid artery (ICA). This accessory vessel traveled parallel to the primary SCA, supplying a portion of its standard vascular territory. This distinctive configuration corresponds to a PTA variant featuring a duplicate SCA, a combination very rarely reported in existing literature. The variant above underscores the embryological origins of the cerebral arterial circle, particularly involving carotid-vertebrobasilar anastomoses. The existence of both a typical and a duplicate SCA constitutes an unprecedented configuration within literature. These vascular anomalies possess clinical significance, especially to neurovascular compression syndromes, such as trigeminal neuralgia, or during surgical and endovascular interventions.
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http://dx.doi.org/10.1007/s00276-025-03673-1 | DOI Listing |
Brain
September 2025
Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 75013 Paris, France.
Adolescence is frequently called the second brain maturation period. In Tourette disorder (TD), the clinical trajectory of tics and associated psychiatric co-morbidities vary significantly across individuals during the transition from adolescents to adulthood. In this study, we aimed to identify patterns of resting-state functional connectivity that differentiate adolescents with TD from their neurotypical peers, and to monitor symptom-specific functional changes over time.
View Article and Find Full Text PDFSurg Case Rep
September 2025
Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.
Introduction: von Hippel-Lindau (VHL) disease is an autosomal dominant hereditary disorder characterized by the development of tumor-like lesions in multiple organs. While central nervous system hemangioblastomas, pancreatic neuroendocrine tumors, and pancreatic cysts are commonly associated with VHL disease, there have been few reported cases of pancreatic hemangioblastoma in patients with VHL disease.
Case Presentation: A male patient in his 30s had been diagnosed with VHL disease and had been followed for cerebellar and spinal hemangioblastomas, and renal cell carcinoma, for which he had undergone several tumor resections, radiation therapy, and a ventriculoperitoneal shunt.
EJNMMI Radiopharm Chem
September 2025
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, 751 85, Sweden.
Background: Alzheimer's disease (AD) is increasingly recognized as a multifactorial disorder with vascular contributions, including a pro-coagulant state marked by fibrin deposition in the brain. Fibrin accumulation may exacerbate cerebral hypoperfusion and neuroinflammation, leading to neurodegeneration. Identifying patients with this pathology could enable targeted anticoagulant therapy.
View Article and Find Full Text PDFCurr Alzheimer Res
September 2025
Department of Neurology, the Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Wuxi, Jiangsu Province, China.
Introduction: The complement receptor 1 (CR1) gene is identified as the one closely associated with Alzheimer's disease (AD). However, there has been no exploration of the imaging alterations associated with the CR1 gene in AD patients of the Han population. The purpose of this study is to investigate the association between the rs6656401 mutation and neuroimaging variations in Han AD patients.
View Article and Find Full Text PDFNeuroscience
September 2025
Department of Psychology & Health Studies, University of Saskatchewan, Saskatoon, Canada. Electronic address:
Attentional processes are crucial to ensure successful reading, and theories of dyslexia propose that dysfunctional attention networks may contribute to the observed reading deficits. The goals of this study were to localize a region of the frontal-eye-field (FEF) involved in both reading and attention and examine its connectivity with regions in the reading and attention networks, given the known role of the FEF in attentional processes and theorized role in reading. In Experiment 1, we revisited the results of our previous hybrid reading and attention study.
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