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Background And Purpose: Cervical spondylosis significantly impacts disability and sleep quality. Along with physiotherapy, selecting an appropriate pillow may improve spinal alignment, relieve neck strain, and enhance sleep. This study protocol aims to evaluate the effectiveness of different pillows in managing cervical spondylosis.
Methods: A participant-blinded, three-arm parallel pilot randomized clinical trial will be conducted at a super-speciality tertiary care hospital. Participants with cervical spondylosis will be randomized into three groups: Group 1 (Cervical pillow + Physiotherapy), Group 2 (Regular pillow + Physiotherapy), and Group 3 (Physiotherapy only). Physiotherapy sessions will include moist heat packs, sub-occipital release, TENS, and postural re-education exercises, delivered three times a week for 4 weeks. Outcome measures-Pittsburgh Sleep Quality Index, Neck Disability Index, Numerical Pain Rating Scale, and Range of Motion-will be assessed at baseline and after 4 weeks.
Results: Descriptive and inferential statistical analyses will be performed on the data. Depending on the results of the normality test, either parametric or non-parametric methods will be utilised for both within-group and between-group analyses.
Discussion: This study adopts a patient-centred approach, aiming to enhance understanding of the complex interplay between sleep, musculoskeletal health, and pillow selection in individuals suffering from cervical spondylosis.
Trial Registration: Clinical Trials Registry of India (CTRI) with trial registration number CTRI/2024/04/065295.
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http://dx.doi.org/10.1002/msc.70150 | DOI Listing |
JAMA Intern Med
September 2025
Bayer CC AG, Basel, Switzerland.
Importance: There is an unmet need for long-term, safe, effective, and hormone-free treatments for menopausal symptoms, including vasomotor symptoms (VMS) and sleep disturbances.
Objective: To evaluate the 52-week efficacy and safety of elinzanetant, a dual neurokinin-targeted therapy, for treating moderate to severe VMS associated with menopause.
Design, Setting, And Participants: OASIS-3 was a double-blind, placebo-controlled, randomized phase 3 clinical trial that was conducted at 83 sites in North America and Europe from August 27, 2021, to February 12, 2024, and included postmenopausal women aged 40 to 65 years who were seeking treatment for moderate to severe VMS (no requirement for a minimum number of VMS events per week).
JAMA Netw Open
September 2025
School of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Importance: The cost-effectiveness of adding early in-bed cycling to usual physiotherapy among adults receiving mechanical ventilation in the intensive care unit (ICU) compared with usual physiotherapy alone is unknown.
Objective: To evaluate the cost-effectiveness of in-bed cycling plus usual physiotherapy compared with usual therapy alone in the Critical Care Cycling to Improve Lower Extremity Strength (CYCLE) randomized clinical trial.
Design, Setting, And Participants: This trial-based economic evaluation with a 90-day time horizon compared early cycling plus usual physiotherapy vs usual physiotherapy alone from a societal perspective.
Crohns Colitis 360
July 2025
Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.
Introduction: Acute severe ulcerative colitis (ASUC) typically requires hospitalization for intravenous (IV) corticosteroid treatment and monitoring. In response to the need to reduce inpatient stays, especially during the COVID-19 pandemic, outpatient treatment models have gained interest. This study evaluated the feasibility, safety, and patient satisfaction of outpatient IV corticosteroid treatment for ASUC.
View Article and Find Full Text PDFSAGE Open Nurs
September 2025
Nursing College, Palestine Polytechnic University, Hebron, Palestine.
Background: Nurse burnout remains a significant global challenge, exacerbated by rotating shift work, which disrupts circadian rhythms and contributes to psychological strain. Burnout is characterized by emotional exhaustion, depersonalization, and reduced personal accomplishment-outcomes that can compromise patient care and workforce stability.
Objective: This systematic review examines the association between rotating shift work and nurse burnout, focusing on how specific shift characteristics influence each burnout dimension and exploring contextual moderators such as organizational support and work environment.