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Premenstrual Dysphoric Disorder (PMDD) and Premenstrual Syndrome (PMS) are prevalent and cause significant distress, yet their psychological mechanisms remain poorly understood. Previous research has linked emotion dysregulation with premenstrual symptoms, but it has often relied on retrospective self-reports, which are prone to bias, and rarely compared PMDD with the milder PMS. Additionally, past studies have not differentiated the heightened emotion dysregulation seen in PMDD from that typically observed in other affective conditions. To address these gaps, we examined the association between emotion dysregulation and premenstrual symptoms in a sample of menstruating individuals meeting criteria for provisional PMDD (N = 39), PMS (N = 160), elevated depression or anxiety (DEPANX; N = 88), and controls (N = 172). All participants completed questionnaires on premenstrual symptom severity and trait global emotion dysregulation, rumination, reappraisal, and suppression. A subset of participants completed a sad mood induction task (PMDD/PMS combined: N = 104; DEPANX: N = 54; Control: N = 161) and reported in vivo use of emotion regulation strategies. Compared to controls, all groups reported greater in vivo and trait rumination, higher trait emotion dysregulation, and lower trait reappraisal. The PMDD group endorsed greater rumination and emotion dysregulation than both the PMS and DEPANX groups. Greater trait emotion dysregulation and rumination predicted higher premenstrual symptom severity across groups. Rumination was the strongest predictor of premenstrual symptom severity between groups, compared to other emotion dysregulation measures. These findings raise the possibility that emotion dysregulation, particularly rumination, plays a role in the aetiology and/or maintenance of impairing premenstrual symptoms, although longitudinal research is needed to further explore these relationships.
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http://dx.doi.org/10.1016/j.jad.2025.119705 | DOI Listing |
Genes Brain Behav
October 2025
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Major depressive disorder is a prevalent and debilitating psychiatric illness that produces significant disability. Clinical data suggest that the pathophysiology of depression is due, in part, to a dysregulation of inflammation and glutamate levels in the brain. The systemic administration of lipopolysaccharide (LPS) has been shown to induce depressive-like behaviors in mice.
View Article and Find Full Text PDFBorderline Personal Disord Emot Dysregul
September 2025
German Center for Mental Health (DZPG), partner site Munich, Munich, Germany.
Background: Emotion dysregulation is a central feature in trauma-associated disorders such as posttraumatic stress disorder (PTSD) and borderline personality disorder (BPD). However, it remains unclear whether emotion dysregulation is a transdiagnostic phenomenon closely linked to childhood trauma, or if disorder-specific alterations in emotion processing exist. Following a multimethodological approach, we aimed to assess and compare the reactivity to and regulation of emotions between patients with BPD and PTSD, as well as healthy controls, and identify associations with childhood trauma.
View Article and Find Full Text PDFJ Safety Res
September 2025
MAIC/UniSC Road Safety Research Collaboration, University of the Sunshine Coast, 90 Sippy Downs Drive, Sippy Downs, Queensland 4556, Australia.
Introduction: Despite decades of research and intervention, aggressive driving behavior (ADB) remains a prevalent risk on our roads. This study aimed to systematically review how drivers' personality traits, perceptual tendencies, self-regulatory capacity, and psychological functioning, have been linked to the engagement of ADBs.
Method: Under guidance of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, a literature search was performed in four databases, followed by a manual search in Google Scholar.
J Neuroimmunol
September 2025
Laboratory of Physiology Pharmacology and Psychopathology, Graduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil. Electronic address:
The mammalian target of rapamycin (mTOR) has a role in immune regulation and neuroplasticity within the brain, influencing various neurological and psychiatric disorders, including bipolar disorder. mTOR signaling, via two complexes, mTORC1 and mTORC2, modulates immune responses by regulating microglial activation, cytokine production, and T-cell function. Dysregulation of these pathways leads to neuroinflammation, a hallmark of several neurological conditions.
View Article and Find Full Text PDFPsychol Sci
September 2025
School of Educational Psychology and Counselling, Faculty of Education, Monash University.
This study examined the sequence and timing of sexual identity development (SID) milestones among Generation Z LGBTQ+ Australians, focusing on variations across subgroups and their relationship with minority stressors. The study included 490 Australian LGBTQ+ individuals aged 16 to 26, predominantly White ( = 389) and assigned female at birth ( = 402), with a balanced distribution between cisgender and gender-diverse participants. Demographic differences in the timing and achievement of SID milestones were found for sexual and gender identity.
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