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http://dx.doi.org/10.1183/20734735.0040-2025 | DOI Listing |
Eur J Med Chem
August 2025
Chemobiology and Pharmacognosy for Health (CPS) Team, Strasbourg Institute for Drug Discovery and Development (ITI IMS), Laboratory of Therapeutic Innovation (LIT), UMR 7200 CNRS/Unistra, Faculty of Pharmacy, 74, route du Rhin, Illkirch, 67400, France; University of Strasbourg Institute for Advanced
Before the 2000s, the antifungal toolbox against invasive fungal infections (IFIs) was only composed of very toxic amphotericin B, weakly selective and nearly unused 5-fluorocytosine and azoles that have been massively used in agriculture and horticulture. The emergence of resistances followed their respective launch, so many antifungals became progressively inefficient whereas the antifungal research was left behind. In the 2000s, echinocandins (ECs) were introduced as a new antifungal class of natural origin and of unprecedented mechanism of action.
View Article and Find Full Text PDFBrief Bioinform
August 2025
Department of Biostatistics, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 1100, Nashville, TN 37232, United States.
Spatial transcriptomics (ST) integrates gene expression data with the spatial organization of cells and their associated histology, offering unprecedented insights into tissue biology. While existing methods incorporate either location-based or histology-informed information, none fully synergize gene expression, histological features, and precise spatial coordinates within a unified framework. Moreover, these methods often exhibit inconsistent performance across diverse datasets and conditions.
View Article and Find Full Text PDFJ Neurochem
September 2025
Institute of Physics, Kazan Federal University, Kazan, Russia.
Neuroimplants are likely major technological breakthroughs of the next decade with the potential for unprecedented social impact. In addition to attractive and miracle-looking possibilities, the major obstacle for the industry is complicated, unpredictable, and unfavorable side effects due to tissue damage, biocompatibility limitations, and foreign body response at the brain-implant interface. Luckily, one major barrier preventing the connection of the neuroimplant to brain cells-the glial scar-has been studied previously for its role in brain trauma.
View Article and Find Full Text PDFMol Cell Proteomics
August 2025
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20007, USA. Electronic address:
O-linked β-N-acetylglucosamine (O-GlcNAc) modification (i.e., O-GlcNAcylation) on proteins is an essential modification in physiology and pathology.
View Article and Find Full Text PDFBiomolecules
July 2025
Department of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Breast cancer, the most prevalent malignancy among women worldwide, exhibits significant heterogeneity, particularly in the tumor microenvironment (TME), which poses challenges for treatment. Spatial transcriptomics (ST) has emerged as a transformative technology, enabling gene expression analysis while preserving tissue spatial architecture. This provides unprecedented insights into tumor heterogeneity, cellular interactions, and disease mechanisms, offering a powerful tool for advancing breast cancer research and therapy.
View Article and Find Full Text PDF