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Article Abstract
Objective: To define the impact of varicoceles (VX) on total testosterone (TT) levels in an aging male population.
Methods: This retrospective analysis of a departmental database assessed patients ≥50 years of age, who had 2 testes, and recorded early morning TT levels. Patient demographics, comorbidity profiles, VX laterality, and VX grade were also analyzed.
Results: Data were retrievable for 776 patients. Mean age was 66±12years. Around 140 (18%) patients had at least 1 VX on examination (VX+). Of these 118 (84%) had unilateral VX while 22 (16%) had bilateral. Mean TT for the VX+ group (336ng/dL±168) was statistically significantly lower than for the VX- group (472ng/dL ±267) (P<.01). Those with bilateral VX had lower TT (297ng/dL) than those with unilateral VX (372ng/dL) (P<.05). While 16% of the total VX+ population had TT levels <300ng/dl, these rates were 11% and 24% in men with unilateral and bilateral VX (P<.01). In those with unilateral VX, there was a relationship between VX grade and testosterone deficiency, with the highest likelihood associated with Grade III (r=0.65, P<.01). There was no association between Grade I and low T levels.
Conclusion: In this population of men older than 50, the presence, laterality, and grade of VX were associated with lower levels of TT.
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| http://dx.doi.org/10.1016/j.urology.2025.06.029 | DOI Listing |
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